Occurrence of BRAF and RET mutation in thyroid patients (CROSBI ID 600705)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Gerić, Marko ; Janušić, Renato ; Šarčević, Božena ; Garaj-Vrhovac, Vera
engleski
Occurrence of BRAF and RET mutation in thyroid patients
Although endocrine cancer in Croatian population represents 2.51% of all cancers, in the few recent years constant increase of incidence was observed. Among cancers of endocrine system, the cancer of thyroid gland is the most frequent. In present study, the aim was to investigate occurrence of BRAF and RET mutations in patients suffering from thyroid illness. The 20 patients were divided into three groups: (1) Papillary thyroid cancer (PTC), (2) Follicular thyroid adenoma (FTA), and (3) other thyroid diseases (Hashimoto, thyreoiditis) patients. Mean age for PTC group was 48.8 years, consisted of 5 volunteers. FTA group mean age was 50.5 years and consisted of 10 volunteers, while the last group mean age was 51.4 years and consisted of 5 volunteers. After analysis of antibody labeled tissue, results showed that all patients had increased levels of either BRAF or RET proteins. PTC patients had 2 positive BRAF and 2 positive RET mutations, while one patient had positive results for both proteins tested. FTA patients, on the other hand, had 2 positive BRAF and 8 positive RET mutations, while patients with other diseases similarly had 4 positive RET and 1 positive both RET and BRAF mutation. Taken together most patients have only one mutated upstream protein which can then activate one of the downstream MAPK pathways. There is possibility that BRAF is under direct control of RET receptor and that is why there is not so many both RET and BRAF mutations.
Papillary thyroid cancer; Follicular thyroid adenoma; BRAF; RET
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Podaci o prilogu
51-51.
2012.
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objavljeno
Podaci o matičnoj publikaciji
Periodicum biologorum
0031-5362
Podaci o skupu
Second Meeting of the Croatian Association for Cancer Research with International Participation
poster
08.11.2012-09.11.2012
Zagreb, Hrvatska
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biologija