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The YEATS domain protein TAF14 exhibits complex regulatory properties across the genome


Nemet, Josipa; Jeličić, Branka; Sopta Marija-Mary
The YEATS domain protein TAF14 exhibits complex regulatory properties across the genome // Mechanisms of eukaryotic transcription / Buratowski, Stephen ; Jones Katherine ; Lis John (ur.).
Cold Spring Harbor, 2013. (poster, nije recenziran, sažetak, znanstveni)


Naslov
The YEATS domain protein TAF14 exhibits complex regulatory properties across the genome

Autori
Nemet, Josipa ; Jeličić, Branka ; Sopta Marija-Mary

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Mechanisms of eukaryotic transcription / Buratowski, Stephen ; Jones Katherine ; Lis John - Cold Spring Harbor, 2013

Skup
Mechanisms of eukaryotic transcription

Mjesto i datum
Cold Spring Harbor, USA, 27-31.08.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Taf14 protein; transcription regulation; genome wide

Sažetak
Taf14, a Saccharomyces cerevisiae protein, physically associates with many critical multisubunit complexes including the general transcription factors TFIID and TFIIF, and the chromatin modifying complexes SWI/SNF, INO80, RSC and NuA3. Taf14 is also a member of the highly conserved YEATS domain superfamily of proteins. Given that little is known about the role of Taf14 in transcription and chromatin remodeling we investigated the impact of TAF14 deletion on genome wide transcription in yeast. Using published microarray data we performed a bioinformatic analysis and found that TATA- containing, SAGA-dependent genes were much more affected by TAF14 deletion than were TFIID- dependent genes. We show that Taf14 repressed genes tend to be extensively regulated, positively by SAGA complex and stress-responsive activators and negatively by a wide number of repressors that act upon promoter chromatin and TBP. We further characterized special regulatory features of Taf14 repressed promoters upon transition from normal to acute heat shock conditions. Using data from a previously reported genome-wide binding study for 200 transcription-related proteins, we analysed Taf14 co-occupancy with subunits of previously reported Taf14-containing complexes and discovered distinct sets of subunits that bind in close vicinity to Taf14 on a significant number of analyzed promoters.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
00981009

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Branka Jeličić (autor)

Avatar Url Josipa Nemet (autor)

Avatar Url Marija-Mary Sopta (autor)

Citiraj ovu publikaciju

Nemet, Josipa; Jeličić, Branka; Sopta Marija-Mary
The YEATS domain protein TAF14 exhibits complex regulatory properties across the genome // Mechanisms of eukaryotic transcription / Buratowski, Stephen ; Jones Katherine ; Lis John (ur.).
Cold Spring Harbor, 2013. (poster, nije recenziran, sažetak, znanstveni)
Nemet, J., Jeličić, B. & Sopta Marija-Mary (2013) The YEATS domain protein TAF14 exhibits complex regulatory properties across the genome. U: Buratowski, S., Jones Katherine & Lis John (ur.)Mechanisms of eukaryotic transcription.
@article{article, year = {2013}, keywords = {Taf14 protein, transcription regulation, genome wide}, title = {The YEATS domain protein TAF14 exhibits complex regulatory properties across the genome}, keyword = {Taf14 protein, transcription regulation, genome wide}, publisherplace = {Cold Spring Harbor, USA} }