Distinct role of Taf14 protein in regulation of SAGA-dependent, TATA-containing genes in yeast (CROSBI ID 600438)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Nemet, Josipa ; Jeličić, Branka ; Sopta Marija-Mary
engleski
Distinct role of Taf14 protein in regulation of SAGA-dependent, TATA-containing genes in yeast
Taf14, a Saccharomyces cerevisiae protein, physically associates with many critical multisubunit complexes including the general transcription factors TFIID and TFIIF, the chromatin modifying complexes SWI/SNF, INO80, RSC and NuA3. Taf14 is a member of the YEATS superfamily of proteins, conserved from bacteria to higher eukaryote, with substantial potential for role in chromatin remodeling mechanisms. Considering poorly described role of Taf14 protein we investigated impact of TAF14 deletion on genome wide transcription in yeast. A range of recent genome wide studies give fascinating insight into cellular strategies for keeping gene expression in tune with physiological needs dictated by the environment. Stress-related genes generally contain TATA boxes, have a predominant regulation by SAGA versus TFIID, prefer negative versus positive regulation by chromatin, and possess higher plasticity of expression. Our transcriptome analysis uncovers that TATA-containing and SAGA- dependent genes were much more affected by TAF14 deletion than were TFIID-dependent genes. We show that Taf14 repressed genes tend to be extensively regulated, , positively by SAGA complex and stress activators and negatively by wide number of repressors that act upon promoter chromatin and TBP.
Taf14 protein; transcription regulation
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Podaci o prilogu
2012.
objavljeno
Podaci o matičnoj publikaciji
Book of abstracts of the 3RD congress of croatian geneticists with international participation
Franekić, Jasna ; Garaj-Vrhovac, Verica
978-953-57128-0-0
Podaci o skupu
Croatian Genetic Society 3rd Congress of Croatian Geneticists with International Participation
predavanje
13.05.2012-16.05.2012
Krk, Hrvatska