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Influence of cadmium on metallothionein expression and products of lipid peroxidation in the organs of hares (Lepus europaeus Pallas)


Tomić Linšak, Dijana; Linšak, Željko; Špirić, Zdravko; Srebočan, Emil; Glad, Marin; Cenov, Arijana; Jakovac, Hrvoje; Milin, Čedomila
Influence of cadmium on metallothionein expression and products of lipid peroxidation in the organs of hares (Lepus europaeus Pallas) // JAT. Journal of applied toxicology, 34 (2014), 3; 289-295 doi:10.1002/jat.2880 (međunarodna recenzija, članak, znanstveni)


Naslov
Influence of cadmium on metallothionein expression and products of lipid peroxidation in the organs of hares (Lepus europaeus Pallas)

Autori
Tomić Linšak, Dijana ; Linšak, Željko ; Špirić, Zdravko ; Srebočan, Emil ; Glad, Marin ; Cenov, Arijana ; Jakovac, Hrvoje ; Milin, Čedomila

Izvornik
JAT. Journal of applied toxicology (0260-437X) 34 (2014), 3; 289-295

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Biomonitoring; cadmium; hares; lipid peroxidation; metallothioneins; selenium

Sažetak
Cadmium occurs naturally in the environment and as an anthropogenic pollutant. Exposure to low concentrations of cadmium is inevitable and may produce toxic effects. Another important aspect of cadmium toxicity is its interaction, often antagonistic, with essential elements such as selenium. The aim of this study was to highlight the risks of long-term exposure to low cadmium concentrations, using a scientific and chemical approach and hares (Lepus europaeus Pallas) as model organisms in a field study. Two study areas were monitored. Levels of cadmium and selenium were quantified in the organs of hares, the expression of metallothioneins I + II and the products of lipid peroxidation were determined. The median cadmium concentrations (wet weight) in the muscle, liver, kidney and brain of hares from an exposed group ranged from 0.033 to 0.037, 0.763 to 1.054, 3.090 to 16.594 and 0.016 to 0.087µg g-1 , respectively ; whereas, the median selenium concentrations (wet weight) ranged from 0.100 to 0.108, 0.153 to 0.332, 0.677 to 0.701 and 0.078 to 0.116µg g-1 , respectively. Expression of the metallothioneins I + II proteins was observed in tissues. Lipid peroxidation (LPO) levels, measured as malondialdehyde (MDA) equivalents, increased with the cadmium concentration. Further research on long-term exposure to low concentrations of cadmium in the environment is needed.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
053-0532400-2362 - Ekotoksikološka istraživanja u divljači (Emil Srebočan, )
062-0621341-0061 - Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva. (Čedomila Milin, )
273-0222882-2698 - Bioindikacija onečišćenja zraka u terestričkim ekosustavima (Zdravko Špirić, )

Ustanove
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Rijeka,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
OIKON d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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