Thermodynamic Study of Inclusion Complexes of Zaleplon with Natural and Modified Cyclodextrins (CROSBI ID 195738)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Jug, Mario ; Jablan, Jasna ; Köver, Katalin ; Weitner, Tin ; Gabričević, Mario
engleski
Thermodynamic Study of Inclusion Complexes of Zaleplon with Natural and Modified Cyclodextrins
The thermodynamics and stoichiometry of zaleplon (ZAL) complexation with different cyclodextrin derivatives (β-CD, HP-β-CD, RAMEB, SBE-β-CD) in aqueous solution was studied by spectrofluorimetry and 1H-NMR spectroscopy in order to obtain a more general understanding of the driving forces behind the inclusion phenomena. Job’s plot derived from the NMR spectral data and statistical analysis of spectrofluorimetric titration data confirmed the formation of equimolar complexes in all systems tested, excluding the possibility of higher order complex formation. Furthermore, thermodynamic parameters obtained by both techniques gave similar and negative values of ΔGo for all complexes, indicating spontaneous inclusion of drug into CDs. From a thermodynamic point of view, two types of inclusions were determined. One is enthalpy driven ZAL complexation with β-CD, HP-β-CD and RAMEB, while the other is entropy driven complexation observed in the case of SBE-β-CD. The mechanisms behind each type of inclusion were discussed in detail.
cyclodextrins; zaleplon; thermodynamics of complexation; fluorescence; 1H NMR
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Podaci o izdanju
79 (3-4)
2014.
391-400
objavljeno
1388-3127
10.1007/s10847-013-0362-6