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Pregled bibliografske jedinice broj: 643792

Thermodynamic Study of Inclusion Complexes of Zaleplon with Natural and Modified Cyclodextrins


Jug, Mario; Jablan, Jasna; Köver, Katalin; Weitner, Tin; Gabričević, Mario
Thermodynamic Study of Inclusion Complexes of Zaleplon with Natural and Modified Cyclodextrins // Journal of inclusion phenomena and macrocyclic chemistry, 79 (2014), 3-4; 391-400 doi:10.1007/s10847-013-0362-6 (međunarodna recenzija, članak, znanstveni)


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Naslov
Thermodynamic Study of Inclusion Complexes of Zaleplon with Natural and Modified Cyclodextrins

Autori
Jug, Mario ; Jablan, Jasna ; Köver, Katalin ; Weitner, Tin ; Gabričević, Mario

Izvornik
Journal of inclusion phenomena and macrocyclic chemistry (1388-3127) 79 (2014), 3-4; 391-400

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cyclodextrins; zaleplon; thermodynamics of complexation; fluorescence; 1H NMR

Sažetak
The thermodynamics and stoichiometry of zaleplon (ZAL) complexation with different cyclodextrin derivatives (β-CD, HP-β-CD, RAMEB, SBE-β-CD) in aqueous solution was studied by spectrofluorimetry and 1H-NMR spectroscopy in order to obtain a more general understanding of the driving forces behind the inclusion phenomena. Job’s plot derived from the NMR spectral data and statistical analysis of spectrofluorimetric titration data confirmed the formation of equimolar complexes in all systems tested, excluding the possibility of higher order complex formation. Furthermore, thermodynamic parameters obtained by both techniques gave similar and negative values of ΔGo for all complexes, indicating spontaneous inclusion of drug into CDs. From a thermodynamic point of view, two types of inclusions were determined. One is enthalpy driven ZAL complexation with β-CD, HP-β-CD and RAMEB, while the other is entropy driven complexation observed in the case of SBE-β-CD. The mechanisms behind each type of inclusion were discussed in detail.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
006-0061117-1244 - Terapijski nanosustavi (Jelena Filipović-Grčić, )
006-0061247-0978 - Gastrin kao kofaktor unosa željeza u organizam. (Mario Gabričević, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Mario Gabričević (autor)

Avatar Url Jasna Jablan (autor)

Avatar Url Mario Jug (autor)

Avatar Url Tin Weitner (autor)

Citiraj ovu publikaciju

Jug, Mario; Jablan, Jasna; Köver, Katalin; Weitner, Tin; Gabričević, Mario
Thermodynamic Study of Inclusion Complexes of Zaleplon with Natural and Modified Cyclodextrins // Journal of inclusion phenomena and macrocyclic chemistry, 79 (2014), 3-4; 391-400 doi:10.1007/s10847-013-0362-6 (međunarodna recenzija, članak, znanstveni)
Jug, M., Jablan, J., Köver, K., Weitner, T. & Gabričević, M. (2014) Thermodynamic Study of Inclusion Complexes of Zaleplon with Natural and Modified Cyclodextrins. Journal of inclusion phenomena and macrocyclic chemistry, 79 (3-4), 391-400 doi:10.1007/s10847-013-0362-6.
@article{article, year = {2014}, pages = {391-400}, DOI = {10.1007/s10847-013-0362-6}, keywords = {cyclodextrins, zaleplon, thermodynamics of complexation, fluorescence, 1H NMR}, journal = {Journal of inclusion phenomena and macrocyclic chemistry}, doi = {10.1007/s10847-013-0362-6}, volume = {79}, number = {3-4}, issn = {1388-3127}, title = {Thermodynamic Study of Inclusion Complexes of Zaleplon with Natural and Modified Cyclodextrins}, keyword = {cyclodextrins, zaleplon, thermodynamics of complexation, fluorescence, 1H NMR} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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