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Pregled bibliografske jedinice broj: 643785

Markers of Coagulation Activation, Endothelial Stimulation, and Inflammation in Dogs with Babesiosis


Barić Rafaj, Renata; Kuleš, Josipa; Selanec, Jelena; Vrkić, Nada; Zovko, Vlasta; Zupančić, Mirjana; Trampus Bakija, Alenka; Matijatko, Vesna; Crnogaj, Martina; Mrljak, Vladimir
Markers of Coagulation Activation, Endothelial Stimulation, and Inflammation in Dogs with Babesiosis // Journal of veterinary internal medicine, 27 (2013), 5; 1172-1178 doi:10.1111/jvim.12146 (međunarodna recenzija, članak, znanstveni)


Naslov
Markers of Coagulation Activation, Endothelial Stimulation, and Inflammation in Dogs with Babesiosis

Autori
Barić Rafaj, Renata ; Kuleš, Josipa ; Selanec, Jelena ; Vrkić, Nada ; Zovko, Vlasta ; Zupančić, Mirjana ; Trampus Bakija, Alenka ; Matijatko, Vesna ; Crnogaj, Martina ; Mrljak, Vladimir

Izvornik
Journal of veterinary internal medicine (0891-6640) 27 (2013), 5; 1172-1178

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hemostasis; inflammatory markers; ntercellular adhesion molecule; von Willebrand factor

Sažetak
Babesia infections in dogs can result in a wide range of clinical and laboratory presentations, including coagulopathy. Expression of intercellular adhesion molecule-1 (ICAM-1) and von Willebrand factor (vWF) in dogs with babesiosis is unknown. Objectives: Whether inflammation in babesiosis triggers activation of ICAM-1 and the coagulation system. Animals: Twelve and 10 dogs with naturally occurring babesiosis before and after antiparasitic treatment, respectively, were compared with 10 healthy dogs. Methods: In this prospective study, diagnosis was made by blood smear examination and confirmed by PCR. C-reactive protein (CRP), soluble intercellular adhesion molecule 1 (sICAM-1), and von Willebrand factor (vWF) levels were measured by a canine ELISA kit, fibrinogen (FIB) and factor VIII activity levels were measured by coagulometric methods, and blood cell counts (WBC, RBC, PLT) were determined with an automatic analyzer. Results: Compared to healthy dogs, the CRP, sICAM-1, and FIB concentrations were significantly increased before therapy and remained high for 3 days after therapy in dogs with babesiosis. vWF activity was significantly decreased in dogs with babesiosis before treatment. FVIII activity did not differ between dogs with babesiosis and healthy dogs. WBC ; RBC and PLT were significantly lower before treatment and normalized by 3 days after treatment. Conclusion and Clinical Importance: A proinflammatory condition in babesiosis appears to influence endothelial dysfunction and hemostatic activity. Although clearly beneficial for the parasite, sequestered blood cells can obstruct blood flow in small vessels, promote an inflammatory state, and could increase the severity of babesiosis.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina, Farmacija



POVEZANOST RADA


Projekt / tema
053-0532266-2220 - Odgovor akutne faze i aktivnost plazmatskih sustava u babeziozi (Vladimir Mrljak, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Veterinarski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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