Stable gastric pentadecapeptide BPC 157 for colitis and multiple sclerosis: Healing of cysteamine-colitis and colon-colon- anastomosis (CROSBI ID 600060)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Sikirić, Predrag ; Kliček, Robert ; Kolenc, Danijela ; Šuran, Jelena ; Drmić, Domagoj ; Brčić, Luka ; Aralica, Gorana ; Seiwerth, Sven ; Ručman, Rudolf
engleski
Stable gastric pentadecapeptide BPC 157 for colitis and multiple sclerosis: Healing of cysteamine-colitis and colon-colon- anastomosis
BPC 157 is interesting as an original anti-ulcer peptide (GEPPPGKPADDAGLV, M.W. 1419) stable in human gastric juice more than 24 hours, successful in trials for inflammatory bowel disease, phase II, wound treatment, no toxicity or side effects reported, LD1 not achieved, effective alone without carrier. The dehiscence of colonic anastomosis is associated with high mortality and morbidity rates. As a result, the problem of healing after a colon resection requires a suitable solution, especially in inflammatory bowel disease with compromised healing. As a possible solution we suggest the use of BPC 157 which may also be effective for treating inflammatory bowel disease complications. After cysteamine (400 mg/kg ir) colon-colon anastomosis was created in rats. The sacrifice was at day 3, 5, 7, and 14. BPC 157 (10μg/kg, 10 ng/kg) was applied ip once daily or in drinking water (0.16 μg/ml/12ml/day) till the sacrifice. Controls poor presentation did not heal cysteamine colitis and colon-colon anastomosis ; BPC 157 simultaneously induced healing of both, the anastomosis and the ulcerative colitis. Thereby, this evidence advocates BPC 157 in inflammatory bowel disease. Interestingly, accordingly with application of agents used in ulcerative colitis (i.e., natalizumab), the most recent evidence suggests its use also in multiple sclerosis therapy.
BPC 157; colitis; multiple sclerosis
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
18-18.
2013.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
FASEB journal
Weissmann, Gerald
Bethesda (MD): Federation of American Societies for Experimental Biology (FASEB)
0892-6638
Podaci o skupu
Experimental Biology 2013
predavanje
20.04.2013-24.04.2013
Boston (MA), Sjedinjene Američke Države