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Pregled bibliografske jedinice broj: 643624

Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression


Meščić, Andrijana; Betzel, Thomas; Müller, Roger; Slavik, Roger; Čermak, Stjepko; Raić- Malić, Silvana; Ametamey, Simon M.
Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression // Molecules, 18 (2013), 7; 8535-8549 doi:10.3390/molecules18078535 (međunarodna recenzija, članak, znanstveni)


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Naslov
Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression

Autori
Meščić, Andrijana ; Betzel, Thomas ; Müller, Roger ; Slavik, Roger ; Čermak, Stjepko ; Raić- Malić, Silvana ; Ametamey, Simon M.

Izvornik
Molecules (1420-3049) 18 (2013), 7; 8535-8549

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acyclic pyrimidine nucleoside analogues ; PCV-like side chain ; fluorination ; radiosynthesis ; positron emission tomography (PET) ; HSV1-TK

Sažetak
With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3- (hydroxymethyl)butyl side chain at N-1 (HHB-5- [18F]FEP) was prepared and evaluated as a potential PET probe. Unlabeled reference compound, HHB-5-FEP, was synthesized via a five-step reaction sequence starting from 5-(2- acetoxyethyl)-4-methoxypyrimidin- 2-one. The radiosynthesis of HHB-[18F]-FEP was accomplished by nucleophilic radiofluorination of a tosylate precursor using [18F]fluoride- cryptate complex in 45% ± 4 (n = 4) radiochemical yields and high purity (> 99%). The biological evaluation indicated the feasibility of using HHB-5-[18F]FEP as a PET radiotracer for monitoring HSV1-tk expression in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
125-0982464-2925 - Razvoj i primjena novih molekula u pozitron-emisijskoj tomografiji (PET) (Raić-Malić, Silvana, MZOS ) ( POIROT)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Poveznice na cjeloviti tekst rada:

doi doi.org www.mdpi.com

Citiraj ovu publikaciju:

Meščić, Andrijana; Betzel, Thomas; Müller, Roger; Slavik, Roger; Čermak, Stjepko; Raić- Malić, Silvana; Ametamey, Simon M.
Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression // Molecules, 18 (2013), 7; 8535-8549 doi:10.3390/molecules18078535 (međunarodna recenzija, članak, znanstveni)
Meščić, A., Betzel, T., Müller, R., Slavik, R., Čermak, S., Raić- Malić, S. & Ametamey, S. (2013) Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression. Molecules, 18 (7), 8535-8549 doi:10.3390/molecules18078535.
@article{article, year = {2013}, pages = {8535-8549}, DOI = {10.3390/molecules18078535}, keywords = {acyclic pyrimidine nucleoside analogues, PCV-like side chain, fluorination, radiosynthesis, positron emission tomography (PET), HSV1-TK}, journal = {Molecules}, doi = {10.3390/molecules18078535}, volume = {18}, number = {7}, issn = {1420-3049}, title = {Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression}, keyword = {acyclic pyrimidine nucleoside analogues, PCV-like side chain, fluorination, radiosynthesis, positron emission tomography (PET), HSV1-TK} }
@article{article, year = {2013}, pages = {8535-8549}, DOI = {10.3390/molecules18078535}, keywords = {acyclic pyrimidine nucleoside analogues, PCV-like side chain, fluorination, radiosynthesis, positron emission tomography (PET), HSV1-TK}, journal = {Molecules}, doi = {10.3390/molecules18078535}, volume = {18}, number = {7}, issn = {1420-3049}, title = {Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression}, keyword = {acyclic pyrimidine nucleoside analogues, PCV-like side chain, fluorination, radiosynthesis, positron emission tomography (PET), HSV1-TK} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • FSTA: Food Science and Technology Abstracts
  • INSPEC
  • MEDLINE


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