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Pregled bibliografske jedinice broj: 643440

Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ


Trsan, Tihana; Busche, A.; Abram, Maja; Wensveen, Felix; Lemmermann, N.A.; Arapović, Maja; Babić, Marina; Tomić, Adriana; Golemac, Mijo; Brinkmann, M.M. et al.
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ // Proceedings of the National Academy of Sciences of the United States of America, 110 (2013), 41; 16550-16555 doi:10.1073/pnas.1310215110 (međunarodna recenzija, članak, znanstveni)


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Naslov
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ

Autori
Trsan, Tihana ; Busche, A. ; Abram, Maja ; Wensveen, Felix ; Lemmermann, N.A. ; Arapović, Maja ; Babić, Marina ; Tomić, Adriana ; Golemac, Mijo ; Brinkmann, M.M. ; Jäger, W. ; Oxenius, A. ; Polić, Bojan ; Krmpotić, Astrid ; Messerle, M. ; Jonjić, Stipan

Izvornik
Proceedings of the National Academy of Sciences of the United States of America (0027-8424) 110 (2013), 41; 16550-16555

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD8 T cell vaccine; RAE-1 gamma; vaccine vector

Sažetak
Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically relevant infections and tumors. NKG2D is one of the most important activating NK cell receptors that plays a role in costimulation of CD8 T cells. Here we demonstrate that the expression of CD8 T-cell epitope of Listeria monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-inducible protein 1-gamma (RAE-1γ) dramatically enhanced the effectiveness and longevity of epitope-specific CD8 T-cell response and conferred protection against a subsequent challenge infection with Listeria monocytogenes. Unexpectedly, the attenuated growth in vivo of the CMV vector expressing RAE-1γ and its capacity to enhance specific CD8 T-cell response were preserved even in mice lacking NKG2D, implying additional immune function for RAE-1γ beyond engagement of NKG2D. Thus, vectors expressing RAE-1γ represent a promising approach in the development of CD8 T-cell-based vaccines.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( POIROT)
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Krmpotić, Astrid, MZOS ) ( POIROT)
062-0621261-1271 - Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava (Polić, Bojan, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Trsan, Tihana; Busche, A.; Abram, Maja; Wensveen, Felix; Lemmermann, N.A.; Arapović, Maja; Babić, Marina; Tomić, Adriana; Golemac, Mijo; Brinkmann, M.M. et al.
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ // Proceedings of the National Academy of Sciences of the United States of America, 110 (2013), 41; 16550-16555 doi:10.1073/pnas.1310215110 (međunarodna recenzija, članak, znanstveni)
Trsan, T., Busche, A., Abram, M., Wensveen, F., Lemmermann, N., Arapović, M., Babić, M., Tomić, A., Golemac, M. & Brinkmann, M. (2013) Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ. Proceedings of the National Academy of Sciences of the United States of America, 110 (41), 16550-16555 doi:10.1073/pnas.1310215110.
@article{article, year = {2013}, pages = {16550-16555}, DOI = {10.1073/pnas.1310215110}, keywords = {CD8 T cell vaccine, RAE-1 gamma, vaccine vector}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, doi = {10.1073/pnas.1310215110}, volume = {110}, number = {41}, issn = {0027-8424}, title = {Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ}, keyword = {CD8 T cell vaccine, RAE-1 gamma, vaccine vector} }
@article{article, year = {2013}, pages = {16550-16555}, DOI = {10.1073/pnas.1310215110}, keywords = {CD8 T cell vaccine, RAE-1 gamma, vaccine vector}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, doi = {10.1073/pnas.1310215110}, volume = {110}, number = {41}, issn = {0027-8424}, title = {Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ}, keyword = {CD8 T cell vaccine, RAE-1 gamma, vaccine vector} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • EconLit


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