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Pregled bibliografske jedinice broj: 642859

Aging-related expression of various transporters in rat kidneys


Sabolić, Ivan; Breljak, Davorka; Micek, Vedran; Herak-Kramberger, Carol M.; Karaica, Dean; Ljubojević, Marija; Vrhovac, Ivana; Rašić, Dubravka; Peraica, Maja; Sekovanić, Ankica et al.
Aging-related expression of various transporters in rat kidneys // Periodicum Biologorum / Vitale, Branko (ur.).
Zagreb: Croatian Society for Natural Sciences, Ruder Boskovic Institute, LASERplus, 2013. (pozvano predavanje, domaća recenzija, sažetak, znanstveni)


Naslov
Aging-related expression of various transporters in rat kidneys

Autori
Sabolić, Ivan ; Breljak, Davorka ; Micek, Vedran ; Herak-Kramberger, Carol M. ; Karaica, Dean ; Ljubojević, Marija ; Vrhovac, Ivana ; Rašić, Dubravka ; Peraica, Maja ; Sekovanić, Ankica ; Jurasović, Jasna ; Anzai, Naohiko ; Koepsell, Hermann

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum Biologorum / Vitale, Branko - Zagreb : Croatian Society for Natural Sciences, Ruder Boskovic Institute, LASERplus, 2013

Skup
3. CONGRESS OF CROATIAN PHYSIOLOGICAL SOCIETY AND 1. REGIONAL CONGRESS OF THE PHYSIOLOGICAL SOCIETIES

Mjesto i datum
Rijeka, Hrvatska, 13-15.09.2013.

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Aging; renal transporters; rat

Sažetak
Aging is an inevitable physiological process characterized by a gradual decline in the functional capabilities regarding personal and environmental needs. In the absence of underlying diseases that accelerate aging (diabetes, cancer, etc…), kidneys are crucial organs for „healthy aging“. Aging kidneys exhibit functional, structural, and genomic losses. The impaired secretory and reabsorptive functions in handling water, organic compounds, drugs, toxins, and the increased tendency to drug-drug interactions, drug-induced adverse reactions, and drug (nephro)toxicity indicate that aging affects various renal transporters, but relevant studies on their activity and/or expression are missing. To initiate such studies, we compared various biochemical, immunochemical, and mRNA parameters in young (Y ; 3 months old) and old (O ; 2 years old) male rats. In comparison with Y, the O rats had higher body mass, lower blood testosterone, lower urine flow and excretion of inorganic ions, and unchanged excretion of glucose. The O rats exhibited lower expression of organic anion (Oat1, Oat3) and cation (Oct1, Oct2) transporters, Na+-phosphate cotransporter NaPi2, and water channel AQP1. The expression of Na/K-ATPase, Oat2, Oat5, Na+-glucose cotransporters (Sglt1, Sglt2), and AQP2 was similar in Y and O rats. We concluded that aging in rats selectively downregulates the renal transporters that are androgen-dependent.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
022-0222148-2146 - Bubrežni prijenosnici u sisavaca; spolne razlike i učinci toksičnih metala (Ivan Sabolić, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus