Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Biologically active heteroaromatic derivatives with amino side chains as potential anticancer agents (CROSBI ID 599764)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Perin, Nataša ; Aleksić, Maja ; Sović, Irena ; Hranjec, Marijana ; Ester, Katja ; Kralj, Marijeta ; Ratkaj, Ivana ; Kraljević Pavelić, Sandra ; Nhili, Raja ; David-Cordonnier, Marie-Hélène et al. Biologically active heteroaromatic derivatives with amino side chains as potential anticancer agents // XXIIth National Meeting on Medicinal Chemistry : Abstract Book. Rim: Italian Chemical Society Division of Medicinal Chemistry, European Federation for Medicinal Chemistry, 2013. str. 77-78

Podaci o odgovornosti

Perin, Nataša ; Aleksić, Maja ; Sović, Irena ; Hranjec, Marijana ; Ester, Katja ; Kralj, Marijeta ; Ratkaj, Ivana ; Kraljević Pavelić, Sandra ; Nhili, Raja ; David-Cordonnier, Marie-Hélène ; Karminski-Zamola, Grace

engleski

Biologically active heteroaromatic derivatives with amino side chains as potential anticancer agents

Over the past few years substituted heterocyclic derivatives have been one of the most extensively studied classes of organic compounds due to their well known biological activities. The development of effective antineoplastic drugs has become one of the most intensively studied aspects of contemporary medicinal chemistry and therefore has been tremendous growth in the number and types of new anticancer agents. One of the most used classes of chemotherapeutic agents in cancer therapy comprise molecules that interact with DNA, such as groove binders, DNA alkylating agents or intercalators. In this report we are presenting the synthesis and antitumor activity of some polyfunctional heterocyclic compounds regarding cyclic benzimidazole, quinolone and isoindoline derivatives bearing different amino side chains. For the synthesis of novel compounds were used classical methods of organic synthesis, photochemical cyclizations and microwave assisted reactions. Structures of prepared compounds were confirmed by means of 1H, 13C NMR, IR and UV spectroscopy. Antiproliferative activity in vitro was tested on several human tumor cell lines. Some of tested compounds showed a differential and significant antiproliferative effect at micromole concentrations. To shed more light on the mechanisms of biological action, additional experiments of interaction with ct-DNA of some active compounds were performed by using UV/Vis, fluorescence and CD spectroscopy and thermal melting experiments as well as topoisomerases I and II inhibition, cell cycle perturbances, subcellular localization and the influence on Enhanced Green Fluorescence protein.

benzimidazo[1; 2-a]quinolines; benzo[b]thieno[2; 3-c]quinolones; derivatives of isoindoline; antiproliferative activity; interaction with ct-DNA

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

77-78.

2013.

objavljeno

Podaci o matičnoj publikaciji

XXIIth National Meeting on Medicinal Chemistry : Abstract Book

Rim: Italian Chemical Society Division of Medicinal Chemistry, European Federation for Medicinal Chemistry

Podaci o skupu

National Meeting on Medicinal Chemistry (13 ; 2013)

poster

10.09.2013-13.09.2013

Rim, Italija

Povezanost rada

Kemija, Temeljne medicinske znanosti