Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors (CROSBI ID 195514)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Štefulj, Jasminka ; Panzenboeck, Ute ; Hof, Patrick R. ; Šimić, Goran
engleski
Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors
The pathogenesis of Alzheimer’s disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.
Alzheimer’s disease ; neurodegeneration ; Amyloid-beta ; cholesterol ; liver-X receptors ; LXR agonists ; neuroinflammation ; Transgenic mouse models
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Podaci o izdanju
4 (3)
2013.
349-356
objavljeno
2081-3856
2081-6936
10.2478/s13380-013-0136-z
Povezanost rada
Biologija, Temeljne medicinske znanosti