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Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors


Štefulj, Jasminka; Panzenboeck, Ute; Hof, Patrick R; Šimić, Goran
Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors // Translational Neuroscience, 4 (2013), 3; 349-356 doi:10.2478/s13380-013-0136-z (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors

Autori
Štefulj, Jasminka ; Panzenboeck, Ute ; Hof, Patrick R ; Šimić, Goran

Izvornik
Translational Neuroscience (2081-3856) 4 (2013), 3; 349-356

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Alzheimer’s disease; neurodegeneration; Amyloid-beta; cholesterol; liver-X receptors; LXR agonists; neuroinflammation; Transgenic mouse models

Sažetak
The pathogenesis of Alzheimer’s disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Jasminka Štefulj, )
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Goran Šimić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Hrvatsko katoličko sveučilište, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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