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Mass Spectrometry of Gangliosides from Human Sensory and Motor Cortex


Flangea, Corina; Fabris, Dragana; Vukelić, Željka; Zamfir, Alina D.
Mass Spectrometry of Gangliosides from Human Sensory and Motor Cortex // Australian journal of chemistry, 66 (2013), 7; 781-790 doi:10.1071/CH13173 (međunarodna recenzija, članak, znanstveni)


Naslov
Mass Spectrometry of Gangliosides from Human Sensory and Motor Cortex

Autori
Flangea, Corina ; Fabris, Dragana ; Vukelić, Željka ; Zamfir, Alina D.

Izvornik
Australian journal of chemistry (0004-9425) 66 (2013), 7; 781-790

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Gangliosides; Adult Human Brain; Sensory and Motor cortex; Mass Spectrometry

Sažetak
Sialylated glycosphingolipids, known as gangliosides, are highly expressed in the central nervous system exhibiting region-specific composition in correlation to the specialised functions of particular brain regions. In the present study high resolution tandem mass spectrometry on a quadrupole time-of-flight instrument with nanoelectrospray was optimised and applied for the first comparative assessment of the ganglioside profile in single specimens of adult human motor and somatosensory cortex. In the second stage, the structural analysis performed by collision induced dissociation tandem MS disclosed the presence in motor cortex of a fucose-ganglioside Fuc-GM1 (d18 : 1/20 : 0) isomer exhibiting both N-acetylneuraminic acid and fucose residues linked to the inner galactose.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-2415 - Strukturno-funkcionalna glikolipidomika moždanog razvitka i maligne alteracije (Željka Vukelić, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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