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Pregled bibliografske jedinice broj: 641608

Differences in epidermal thickness and expression of apoptosis regulatory proteins in the skin of patients with chronic renal failure and pruritus


Mirić Kovačević, Lina; Puizina-Ivić, Neira; Ljutić, Dragan; Mardešić Brakus, Snježana; Kalibović Govorko, Danijela; Jeličić, Ivo; Mirić, Dino; Rešić, Jasminka; Saraga-Babić, Mirna
Differences in epidermal thickness and expression of apoptosis regulatory proteins in the skin of patients with chronic renal failure and pruritus // Acta Histochemica, 115 (2013), 2; 144-150 doi:10.1016/j.acthis.2012.06.003 (međunarodna recenzija, članak, znanstveni)


Naslov
Differences in epidermal thickness and expression of apoptosis regulatory proteins in the skin of patients with chronic renal failure and pruritus

Autori
Mirić Kovačević, Lina ; Puizina-Ivić, Neira ; Ljutić, Dragan ; Mardešić Brakus, Snježana ; Kalibović Govorko, Danijela ; Jeličić, Ivo ; Mirić, Dino ; Rešić, Jasminka ; Saraga-Babić, Mirna

Izvornik
Acta Histochemica (0065-1281) 115 (2013), 2; 144-150

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chronic renal failure ; skin thickness ; pruritus ; apoptosis

Sažetak
Chronic renal failure is often associated with skin itching (pruritus) in dialysis patients. In order to investigate the possible causes of pruritus, the epidermis of the thigh of 12 dialysis patients and 4 controls from patients without renal disease were examined. The sections of the epidermis were measured and immunohistochemically analyzed using antibodies to Bcl-2, Bax, caspase-3 proteins and TUNEL method. While the mean thickness of normal epidermis was 53 pm, in dialysis patients it ranged between 23 and 34 mu m during the 3-5 year period on dialysis. Compared to normal skin, the fine balance between the Bcl-2 and Bax proteins did not greatly change in the epidermis of dialysis patients during the three years of dialysis. Following five-year dialysis, the epidermis displayed increased Bax and decreased Bcl-2 expression in the basal and intermediate epidermal layers, as well as the presence of apoptotic cells (TUNEL and caspase-3 positive) both in the superficial and intermediate epidermal layers. Our study demonstrated the predominant expression of cell death Bax proteins over cell survival Bcl-2 proteins, and apoptotic cells in the deeper layers of the epidermis in patients on long-term dialysis. We speculate that the thinning of the epidermis might be associated with the appearance of dead cells in the deeper epidermal layers, while the changed internal milieu of epidermal cells could possibly affect the intra-epidermal nerve endings thus leading to the sensation of pruritus.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Citiraj ovu publikaciju

Mirić Kovačević, Lina; Puizina-Ivić, Neira; Ljutić, Dragan; Mardešić Brakus, Snježana; Kalibović Govorko, Danijela; Jeličić, Ivo; Mirić, Dino; Rešić, Jasminka; Saraga-Babić, Mirna
Differences in epidermal thickness and expression of apoptosis regulatory proteins in the skin of patients with chronic renal failure and pruritus // Acta Histochemica, 115 (2013), 2; 144-150 doi:10.1016/j.acthis.2012.06.003 (međunarodna recenzija, članak, znanstveni)
Mirić Kovačević, L., Puizina-Ivić, N., Ljutić, D., Mardešić Brakus, S., Kalibović Govorko, D., Jeličić, I., Mirić, D., Rešić, J. & Saraga-Babić, M. (2013) Differences in epidermal thickness and expression of apoptosis regulatory proteins in the skin of patients with chronic renal failure and pruritus. Acta Histochemica, 115 (2), 144-150 doi:10.1016/j.acthis.2012.06.003.
@article{article, year = {2013}, pages = {144-150}, DOI = {10.1016/j.acthis.2012.06.003}, keywords = {chronic renal failure, skin thickness, pruritus, apoptosis}, journal = {Acta Histochemica}, doi = {10.1016/j.acthis.2012.06.003}, volume = {115}, number = {2}, issn = {0065-1281}, title = {Differences in epidermal thickness and expression of apoptosis regulatory proteins in the skin of patients with chronic renal failure and pruritus}, keyword = {chronic renal failure, skin thickness, pruritus, apoptosis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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