engleski

Comparison of the accumulation of ochratoxin A residues in treated pig tissues

Driven by the observation that the mycotoxin ochratoxin A (OTA) often contaminates cereals and feed in this European region, the aim of the study was to compare the accumulation of OTA residues in different pig tissues exposed to sub-chronic treatment. The treated animal group (n = 5) was administered 300 μg OTA/kg of feed during a 30-day period, whereas the control group (n = 5) was left untreated. OTA concentrations were quantified using high performance liquid chromatography with fluorescence detection (HPLC-FD) that had shown acceptable validation results when it comes to all investigated tissues, with mean recoveries spanning from 88.2% to 96.1% and acceptable mean inter- and intra-day relative standard deviations (<10%). OTA concentrations determined in treated animal tissues ranged from 4.59 ± 1.45 μg/kg in the adipose tissue to 15.31 ± 2.77 μg/kg in the kidney. The results pointed out that sub-chronic pig exposure to the OTA dose frequently found in cereals and feed leads to the accumulation of OTA residues in the concentrations that are the highest in the kidney, then lungs, liver, blood, spleen, and heart, and the lowest in the adipose tissue.

Ochratoxin A; Accumulation; Residues; Pig tissues; HPLC-FD

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