The regions of alpha-neurotoxin binding on the extracellular part of the alpha-subunit of human acetylcholine receptor (CROSBI ID 195278)
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Mulac-Jeričević, Biserka ; Manshouri, T. ; Yokoi, T. ; Atassi, M.Z.
engleski
The regions of alpha-neurotoxin binding on the extracellular part of the alpha-subunit of human acetylcholine receptor
A set of 18 synthetic uniform overlapping peptides spanning the entire extracellular part (residues 1-210) of the alpha-subunit of human acetylcholine receptor were studied for their binding activity of 125I-labeled alpha-bungarotoxin and cobratoxin. A major toxin-binding region was found to reside within peptide alpha 122-138. In addition, low-binding activities were obtained with peptides alpha 34-49 and alpha 194-210. It is concluded that the region within residues alpha 122-138 constitutes a universal major toxin-binding region for acetylcholine receptor of various species.
acetylcholine receptor; bungarotoxin; synthetic peptides
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Temeljne medicinske znanosti