engleski

Treatment of Cervical Intraepithelial Neoplasia by 5-Fluorouracil, Interferon or Albothyl in the Presence/Absence of High-Risk of Human Papillomavirus.

Objectives: The primary objective of this preliminary study was to test the suitability of 5-fluorouracil ointment ; interferon ointment and albothyl concentrate as alternative therapies for the treatment of cervical intraepithelial neoplasia (CIN) in the presence/absence of high risk human papilloma virus (hrHPV), as well as to compare the three treatment approaches. The secondary objective included the determination of causative factors of the genital infections and their correlation with various predictor variables. Patients and Methods: 45 patients aged 18-64 years diagnosed with CIN were included in the study. 15 patients without hrHPV were treated with albothyl. The other 30 patients were randomly divided into two subgroups and treated either by 5-fluorouracil or by interferon. The results were evaluated by canonical correlation analysis, multiple regression, general regression model and odds ratio. Results and Conclusion: Age, the presence of bacterial infection and number of births were the variables which showed the highest correlation with CIN and hrHPV. After a month-long treatment, total clearance was observed in 10 patients (22.2%) and lower grade lesions were observed in 22 of them (48.9%). Total clearance of hrHPV was found in 93.3% of the patients. There was no significant difference among the three therapeutic approaches. To the contrary, the type of contraception during the treatment had a significant influence on the outcome of the therapy. The obtained results confirmed that all the three selected approaches may be used successfully for the treatment of CIN lesions and represent a suitable alternative to surgical treatment.

Bacterial infection; Non-invasive methods; Treatment modalities;

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