Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 640761

Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice


Domitrović, Robert; Potočnjak, Iva; Crnčević- Orlić, Željka; Škoda, Marko
Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice // Food and chemical toxicology, 66 (2014), 321-328 doi:10.1016/j.fct.2014.02.002 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 640761 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice

Autori
Domitrović, Robert ; Potočnjak, Iva ; Crnčević- Orlić, Željka ; Škoda, Marko

Izvornik
Food and chemical toxicology (0278-6915) 66 (2014); 321-328

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rosmarinic acid ; cisplatin ; nephrotoxicity ; oxidative stress ; inflammation ; apoptosis

Sažetak
Rosmarinic acid (RA) is a natural phenolic compound with a broad range of applications, from food preservatives to cosmetics. Increasing amounts of evidence suggests its beneficial effects against various pathological conditions. The aim of this study was to investigate the therapeutic activity of rosmarinic acid (RA) against cisplatin (CP)-induced nephrotoxicity. RA was administered by oral gavage at doses of 1, 2 and 5mg/kg for two successive days, 48h after intraperitoneal CP injection (13mg/kg). Twenty four hours later, mice were sacrificed. Treatment with RA significantly ameliorated histopathological changes and the increase in serum creatinine and blood urea nitrogen (BUN) induced by CP. Oxidative stress induced by CP, evidenced by increased renal 4-hydroxynonenal (4- HNE), cytochrome P450 2E1 (CYP2E1) and heme oxygenase (HO-1) expression, was significantly reduced by RA administration. Moreover, RA inhibited the expression of nuclear factor-kappaB (NF-κB) and tumor necrosis factor-α (TNF-α), indicating the inhibition of inflammation. Additionally, RA exhibited antiapoptotic activity through the reduction of p53, phosphorylated p53 and active caspase-3 expression in the kidneys. These findings show that RA ameliorates CP-induced oxidative stress, inflammation and apoptosis in the kidneys. The nephroprotective activity of RA could be, at least in part, attributed to reduced CYP2E1 expression.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
Sveučilište u Rijeci
potpora 13.06.1.2.24
062-0000000-3554 - Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre (Domitrović, Robert, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Domitrović, Robert; Potočnjak, Iva; Crnčević- Orlić, Željka; Škoda, Marko
Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice // Food and chemical toxicology, 66 (2014), 321-328 doi:10.1016/j.fct.2014.02.002 (međunarodna recenzija, članak, znanstveni)
Domitrović, R., Potočnjak, I., Crnčević- Orlić, Ž. & Škoda, M. (2014) Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice. Food and chemical toxicology, 66, 321-328 doi:10.1016/j.fct.2014.02.002.
@article{article, year = {2014}, pages = {321-328}, DOI = {10.1016/j.fct.2014.02.002}, keywords = {rosmarinic acid, cisplatin, nephrotoxicity, oxidative stress, inflammation, apoptosis}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2014.02.002}, volume = {66}, issn = {0278-6915}, title = {Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice}, keyword = {rosmarinic acid, cisplatin, nephrotoxicity, oxidative stress, inflammation, apoptosis} }
@article{article, year = {2014}, pages = {321-328}, DOI = {10.1016/j.fct.2014.02.002}, keywords = {rosmarinic acid, cisplatin, nephrotoxicity, oxidative stress, inflammation, apoptosis}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2014.02.002}, volume = {66}, issn = {0278-6915}, title = {Nephroprotective activities of rosmarinic acid against cisplatin-induced kidney injury in mice}, keyword = {rosmarinic acid, cisplatin, nephrotoxicity, oxidative stress, inflammation, apoptosis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font