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Pregled bibliografske jedinice broj: 640003

Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling


Car, Željka; Hrenar, Tomica; Petrović Peroković, Vesna; Ribić, Rosana; Seničar, Mateja; Tomić, Srđanka
Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling // Chemical biology & drug design, 84 (2014), 393-401 doi:10.1111/cbdd.12329 (međunarodna recenzija, članak, znanstveni)


Naslov
Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling

Autori
Car, Željka ; Hrenar, Tomica ; Petrović Peroković, Vesna ; Ribić, Rosana ; Seničar, Mateja ; Tomić, Srđanka

Izvornik
Chemical biology & drug design (1747-0277) 84 (2014); 393-401

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Escherichia coli; FimH lectin; hemagglutination; molecular modeling; N-aryl-substituted 3-hydroxypyridine-4- ones; a-mannopyranosides

Sažetak
Structural alterations of the aglycon portions of amannosides influence their inhibitory potency toward type 1-fimbriated Escherichia coli. The aim of our work was to prepare and explore inhibitory properties of novel mannosylated N-aryl-substituted 3- hydroxypyridine-4-ones because they possess needed structural characteristics as possible FimH antagonists. Hemagglutination inhibitory tests showed that the examined 3- hydroxypyridine-4-one a-mannosides exhibited better inhibitory activity than methyl a-D- mannopyranoside used as a reference compound. Molecular modeling studies revealed the specific interactions responsible for the observed binding activities toward the mannosespecific FimH lectin. The activity depends on the substituent in p-position on the aglycon aromatic ring.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
119-1191342-2959 - Spektroskopska analiza nezasićenih sustava i spojeva metala (Snežana Miljanić, )
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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