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Pregled bibliografske jedinice broj: 640003

Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling


Car, Željka; Hrenar, Tomica; Petrović Peroković, Vesna; Ribić, Rosana; Seničar, Mateja; Tomić, Srđanka
Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling // Chemical biology & drug design, 84 (2014), 393-401 doi:10.1111/cbdd.12329 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 640003 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling

Autori
Car, Željka ; Hrenar, Tomica ; Petrović Peroković, Vesna ; Ribić, Rosana ; Seničar, Mateja ; Tomić, Srđanka

Izvornik
Chemical biology & drug design (1747-0277) 84 (2014); 393-401

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Escherichia coli; FimH lectin; hemagglutination; molecular modeling; N-aryl-substituted 3-hydroxypyridine-4- ones; a-mannopyranosides

Sažetak
Structural alterations of the aglycon portions of amannosides influence their inhibitory potency toward type 1-fimbriated Escherichia coli. The aim of our work was to prepare and explore inhibitory properties of novel mannosylated N-aryl-substituted 3- hydroxypyridine-4-ones because they possess needed structural characteristics as possible FimH antagonists. Hemagglutination inhibitory tests showed that the examined 3- hydroxypyridine-4-one a-mannosides exhibited better inhibitory activity than methyl a-D- mannopyranoside used as a reference compound. Molecular modeling studies revealed the specific interactions responsible for the observed binding activities toward the mannosespecific FimH lectin. The activity depends on the substituent in p-position on the aglycon aromatic ring.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
119-1191342-2959 - Spektroskopska analiza nezasićenih sustava i spojeva metala (Miljanić, Snežana, MZOS ) ( POIROT)
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Tomić-Pisarović, Srđanka, MZOS ) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Car, Željka; Hrenar, Tomica; Petrović Peroković, Vesna; Ribić, Rosana; Seničar, Mateja; Tomić, Srđanka
Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling // Chemical biology & drug design, 84 (2014), 393-401 doi:10.1111/cbdd.12329 (međunarodna recenzija, članak, znanstveni)
Car, Ž., Hrenar, T., Petrović Peroković, V., Ribić, R., Seničar, M. & Tomić, S. (2014) Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling. Chemical biology & drug design, 84, 393-401 doi:10.1111/cbdd.12329.
@article{article, author = {Car, \v{Z}eljka and Hrenar, Tomica and Petrovi\'{c} Perokovi\'{c}, Vesna and Ribi\'{c}, Rosana and Seni\v{c}ar, Mateja and Tomi\'{c}, Sr\djanka}, year = {2014}, pages = {393-401}, DOI = {10.1111/cbdd.12329}, keywords = {Escherichia coli, FimH lectin, hemagglutination, molecular modeling, N-aryl-substituted 3-hydroxypyridine-4- ones, a-mannopyranosides}, journal = {Chemical biology and drug design}, doi = {10.1111/cbdd.12329}, volume = {84}, issn = {1747-0277}, title = {Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling}, keyword = {Escherichia coli, FimH lectin, hemagglutination, molecular modeling, N-aryl-substituted 3-hydroxypyridine-4- ones, a-mannopyranosides} }
@article{article, author = {Car, \v{Z}eljka and Hrenar, Tomica and Petrovi\'{c} Perokovi\'{c}, Vesna and Ribi\'{c}, Rosana and Seni\v{c}ar, Mateja and Tomi\'{c}, Sr\djanka}, year = {2014}, pages = {393-401}, DOI = {10.1111/cbdd.12329}, keywords = {Escherichia coli, FimH lectin, hemagglutination, molecular modeling, N-aryl-substituted 3-hydroxypyridine-4- ones, a-mannopyranosides}, journal = {Chemical biology and drug design}, doi = {10.1111/cbdd.12329}, volume = {84}, issn = {1747-0277}, title = {Mannosylated N-Aryl Substituted 3- Hydroxypyridine-4- Ones: Synthesis, Hemagglutination Inhibitory Properties, and Molecular Modeling}, keyword = {Escherichia coli, FimH lectin, hemagglutination, molecular modeling, N-aryl-substituted 3-hydroxypyridine-4- ones, a-mannopyranosides} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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