Plasma nitrite concentrations decrease after hyperoxia-induced oxidative stress in healthy humans (CROSBI ID 599116)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Modun, Darko ; Krnić, Mladen ; Vuković, Jonatan ; Kokić, Višnja ; Kukoč Modun, Lea ; Tsikas, Dimitrios ; Dujić, Željko
engleski
Plasma nitrite concentrations decrease after hyperoxia-induced oxidative stress in healthy humans
Background: We measured plasma nitrite, the biochemical marker of endothelial nitric oxide (•NO) synthesis, before and after hyperoxia, in order to test the hypothesis that hyperoxia-induced vasoconstriction is a consequence of reduced bioavailability of •NO due to elevated oxidative stress. Methods: Ten healthy males breathed 100% normobaric O2 for 30 min between the 15th and 45th min of the 1 h study protocol. Plasma nitrite and malondialdehyde (MDA), arterial stiffness (indicated by augmentation index, AIx) and arterial oxygen (PtcO2) pressure were measured in the 1st, 15th, 45th and 60th minute of the study. Results: Breathing of normobaric 100% oxygen during 30 min caused an increase of PtcO2 (from 75 ± 2 to 412 ± 25 mm Hg), AIx (from −63 ± 4 to −51 ± 3%) and MDA (from 152 ± 13 to 218 ± 15 nmol/L) and a decrease in plasma nitrite (from 918 ± 58 to 773 ± 55 nmol/L). During the 15-min recovery phase the plasma nitrite, AIx and MDA values remained altered. Conclusions: This study suggests that the underlying mechanism of hyperoxia-induced vasoconstriction may result from reduced •NO bioavailability due to elevated and sustained oxidative stress.
nitric oxide; oxygen; vasoconstriction
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Podaci o prilogu
A88-A88.
2012.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
BMC pharmacology & toxicology
Holzer, Peter ; Griesbacher, Thomas
Graz: BioMed Central
2050-6511
Podaci o skupu
18th Scientific Symposium of the Austrian Pharmacological Society (APHAR)
poster
20.09.2012-21.09.2012
Graz, Austrija
Povezanost rada
Kemija, Temeljne medicinske znanosti, Kliničke medicinske znanosti