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Non-human errors are the main source of falsely determined alleles in DNA databases (CROSBI ID 599057)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Džijan, Snježana ; Ćurić, Goran ; Pavlinić, Dinko ; Hercog, Rajna ; Lauc, Gordan Non-human errors are the main source of falsely determined alleles in DNA databases // The 6th ISABS Conference on Human Genome Project Based Applications in Forensic Science, Anthropology and Individualized Medicine: The book of abstracts / Vuk-Pavlović, Stanimir ; Primorac, Dragan ; Schanfield, Moses (ur.). Zagreb: International Society for Applied Biological Sciences (ISABS), 2009. str. 79-79

Podaci o odgovornosti

Džijan, Snježana ; Ćurić, Goran ; Pavlinić, Dinko ; Hercog, Rajna ; Lauc, Gordan

engleski

Non-human errors are the main source of falsely determined alleles in DNA databases

Aiming to estimate frequency of various types of errors that may have occurred during the process of identification of victims of war in Croatia we compared genotypes of 911 parent-child pairs in the database of nearly 3500 relatives of missing people. By repeated analysis of mismatched genotypes we identified seven errors in the database. Out of these seven errors, falsely genotypes alleles were caused by human error, while the remaining five errors were caused by allelic dropout or electrophoretic aberrations. An important observation is that all three observed allelic dropouts occurred at D2S1338 locus which is the largest fragment amplified by the AmpFlSTR Identifiler kit. Larger alleles at this locus frequently amplify with lower efficiency, sometimes not reaching the detection level indicating that additional proofreading procedures should be performed when homozygous D2S1338 locus is being reported.

DNA typing; Human identification; STR loci; DNA database; Quality control

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

79-79.

2009.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

The 6th ISABS Conference on Human Genome Project Based Applications in Forensic Science, Anthropology and Individualized Medicine: The book of abstracts

Vuk-Pavlović, Stanimir ; Primorac, Dragan ; Schanfield, Moses

Zagreb: International Society for Applied Biological Sciences (ISABS)

Podaci o skupu

The 6th ISABS Conference on Human Genome Project Based Applications in Forensic Science, Anthropology and Individualized Medicine

poster

01.06.2009-05.06.2009

Split, Hrvatska

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti