hrvatski

Klik reakcijama do novog aciklonukleozida

The aim of this work was to synthesize new acyclonucleosides by click reaction. Target compounds are pyrimidine derivatives with penciclovir chain at the N-1 and N-3 position, and 1, 4-disubstituted 1, 2, 3-triazolic ring at the C-5 of the pyrimidine. Compounds 6 and 11 were prepared by the copper-catalyzed azide-alkyne cycloaddition. The structures of all synthesized compounds were confirmed by 1H and 13C NMR spectroscopy.

aciklonukleozidi ; klik kemija ; 1 ; 3-dipolarna cikloadicija katalizirana bakrom (I)

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