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„Compensated hyperosmolarity“ of cerebrospinal fluid and the development of hydrocephalus


Klarica, Marijan; Miše, Branko; Vladić, Anton; Radoš, Marko; Orešković, Darko
„Compensated hyperosmolarity“ of cerebrospinal fluid and the development of hydrocephalus // Neuroscience, 248 (2013), 278-289 doi:10.1016/j.neuroscience.2013.06.022 (međunarodna recenzija, članak, znanstveni)


Naslov
„Compensated hyperosmolarity“ of cerebrospinal fluid and the development of hydrocephalus

Autori
Klarica, Marijan ; Miše, Branko ; Vladić, Anton ; Radoš, Marko ; Orešković, Darko

Izvornik
Neuroscience (0306-4522) 248 (2013); 278-289

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cerebrospinal fluid ; hydrocephalus ; cerebrospinal fluid hydrodynamics ; cerebrospinal fluid hyperosmolarity ; intracranial pressure

Sažetak
Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of 3H2O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly faster, hence causing a significant increase in intracranial pressure. The noted phenomenon in which intracranial pressure still significantly increases, but in which the hyperosmolarity of the cerebrospinal fluid is no longer present, was named “compensated hyperosmolarity”. In the case of the sub-chronic application of hyperosmolar solutions into cat ventricles, we observed an increase in cerebrospinal fluid volume and a more pronounced development of hydrocephalus in the area of application, but without significant increase in intracranial pressure and without blockage of cerebrospinal fluid pathways. These results support the newly proposed hypothesis of cerebrospinal fluid hydrodynamics and the ability to develop new strategies for the treatment of cerebrospinal fluid-related diseases.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema

098-1080231-2328 - Hidrodinamika cerebrospinalnog fluida (Darko Orešković, )
108-1080231-0023 - Patofiziologija cerebrospinalnog likvora i intrakranijskog tlaka (Marijan Klarica, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinička bolnica "Sveti Duh",
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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