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Pregled bibliografske jedinice broj: 637241

Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.


Jordan, S.; Ruzsics, Z.; Mitrović, Maja; Baranek, T.; Arapović, Jurica; Krmpotić, Astrid; Vivier, E.; Dalod, M.; Jonjić, Stipan; Döelken, L.; Koszinowski, U.H.
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection. // Cell host & microbe, 13 (2013), 5; 535-545 doi:10.1016/j.chom.2013.04.007 (međunarodna recenzija, članak, znanstveni)


Naslov
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.

Autori
Jordan, S. ; Ruzsics, Z. ; Mitrović, Maja ; Baranek, T. ; Arapović, Jurica ; Krmpotić, Astrid ; Vivier, E. ; Dalod, M. ; Jonjić, Stipan ; Döelken, L. ; Koszinowski, U.H.

Izvornik
Cell host & microbe (1931-3128) 13 (2013), 5; 535-545

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
extramedullary hematopoiesis (EMH); MCMV; NK cell receptors Ly49H or NKG2D

Sažetak
The immune response against a variety of pathogens can lead to activation of blood formation at ectopic sites, a process termed extramedullary hematopoiesis (EMH). The underlying mechanisms of EMH have been enigmatic. Investigating splenic EMH in mice infected with murine cytomegalovirus (MCMV), we find that, while cells of the adaptive immune system were dispensable for EMH, natural killer (NK) cells were essential. EMH required recognition of infected cells via activating NK cell receptors Ly49H or NKG2D, and correspondingly, viral interference with NK cell recognition abolished EMH. Surprisingly, development of EMH was not induced by NK cell-derived cytokines but was dependent on perforin-mediated cytotoxicity in order to control virus spread. Spreading virus reduced the numbers of F4/80(+) macrophages that were crucial for inflammatory EMH. Hence, whereas MCMV suppresses inflammation-induced EMH, NK cells confine virus spread, thereby protecting extramedullary hematopoietic niches and facilitating EMH.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Jordan, S.; Ruzsics, Z.; Mitrović, Maja; Baranek, T.; Arapović, Jurica; Krmpotić, Astrid; Vivier, E.; Dalod, M.; Jonjić, Stipan; Döelken, L.; Koszinowski, U.H.
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection. // Cell host & microbe, 13 (2013), 5; 535-545 doi:10.1016/j.chom.2013.04.007 (međunarodna recenzija, članak, znanstveni)
Jordan, S., Ruzsics, Z., Mitrović, M., Baranek, T., Arapović, J., Krmpotić, A., Vivier, E., Dalod, M., Jonjić, S., Döelken, L. & Koszinowski, U. (2013) Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.. Cell host & microbe, 13 (5), 535-545 doi:10.1016/j.chom.2013.04.007.
@article{article, year = {2013}, pages = {535-545}, DOI = {10.1016/j.chom.2013.04.007}, keywords = {extramedullary hematopoiesis (EMH), MCMV, NK cell receptors Ly49H or NKG2D}, journal = {Cell host and microbe}, doi = {10.1016/j.chom.2013.04.007}, volume = {13}, number = {5}, issn = {1931-3128}, title = {Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.}, keyword = {extramedullary hematopoiesis (EMH), MCMV, NK cell receptors Ly49H or NKG2D} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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