engleski

NKG2D -dependent and -independent immune function of RAE-1: superior induction and maintenance of protective CD8 T cells in mice infected with MCMV vector expressing RAE-1'

The story is about the interesting finding that MCMV vector expressing NKG2D ligand RAE-1 and foreign CD8 epitope induces robust CD8 response, in spite of its dramatic attenuation in vivo. We worked out the mechanism to some extent and it looks like such a virus enhances direct antigen presentation. Above all, by using NKG2D k.o. mouse, we also observed this enhancing immunogenicity of this virus vector, suggesting that there must be another immune function for RAE-1.

MCMV; NKG2D ligand Rae-1; innate immunity

nije evidentirano