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Structural Elucidation Studies of 15-Membered Azalide Macrocycles using H/D Exchange and ESI-MSn


Gembarovski, Dubravka; Gabelica Marković, Vesna; Galić, Nives
Structural Elucidation Studies of 15-Membered Azalide Macrocycles using H/D Exchange and ESI-MSn // Journal of pharmaceutical and biomedical analysis, 86 (2013), 1-10 doi:10.1016/j.jpba.2013.07.011 (međunarodna recenzija, članak, znanstveni)


Naslov
Structural Elucidation Studies of 15-Membered Azalide Macrocycles using H/D Exchange and ESI-MSn

Autori
Gembarovski, Dubravka ; Gabelica Marković, Vesna ; Galić, Nives

Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 86 (2013); 1-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
15-Membered Azalide Aglycone; macrolides; ESI-MSn; H/D exchange; fragmentation; sodium adducts

Sažetak
A comprehensive study of fragmentation pathways of 15-membered azalide macrocycles using electrospray ionisation with multistage mass spectrometry (ESI-MSn) is presented in this work. Hydrogen/deuterium (H/D) exchange experiments and high-resolution mass spectrometry were used to investigate the proposed fragmentation pathways. In addition, the fragmentation patterns of sodium adduct ions [M+Na]+ of the macrocycles were also investigated as the presence of an alkali metal interacting with the aglycone ring influences the product-ion spectra.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Predrag Novak, )
119-1191342-2960 - Elektroliti i koordinacijske reakcije u otopini (Vladislav Tomišić, )

Ustanove
Prirodoslovno-matematički fakultet, Zagreb,
Fidelta d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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