engleski

Structural Elucidation Studies of 15-Membered Azalide Macrocycles using H/D Exchange and ESI-MSn

A comprehensive study of fragmentation pathways of 15-membered azalide macrocycles using electrospray ionisation with multistage mass spectrometry (ESI-MSn) is presented in this work. Hydrogen/deuterium (H/D) exchange experiments and high-resolution mass spectrometry were used to investigate the proposed fragmentation pathways. In addition, the fragmentation patterns of sodium adduct ions [M+Na]+ of the macrocycles were also investigated as the presence of an alkali metal interacting with the aglycone ring influences the product-ion spectra.

15-Membered Azalide Aglycone; macrolides; ESI-MSn; H/D exchange; fragmentation; sodium adducts

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