engleski

Kidney function in visceral obesity is not related to the adiponectin

Introduction and Aims: Visceral obesity is acknowledged risk factor for CKD.Adiponectin (AP) was considered to be related with beneficial clinical course.However, some authors reported opposite results.Our aim was to analyze relationship of AP with blood pressure(BP) values and kidney function in rural population. Methods: Out of 2487 enrolled subjects in cross sectional survey 257(97m and 160f) were included in this analyses.Anthropometric parameters, office BP was measured using Omron device following ESH guidelines ; albumin/creatinine ratio(ACR), eGFR, alpha 1 microglobulin-creatinine, fasting blood glucose, total cholesterol, HOMA-IR index and AP levels were determined. Results: In the subgroup of untreated hypertensives stage 1, viscerally obese subjects comparing to lean had higher values of systolic BP (*148.25 vs.143.40 ; p=0.03), HOMA- IR(*2.72 ; vs.1.98 ; p=0.015), hsCRP (*2.80 ; vs.1.60 ; p=0.05) and ACR(*5.74 ; vs.4.10 ; p=0.08) and lower eGFR(*76.05 ; vs.77.68 ; p=0.027).No differences in AP values were found(9.85 ; vs.7.35 ; p=0.28).In the normotensive subgroup, viscerally obese had higher HOMA- IR(*2.64 ; vs.*1.36 ; p<0.0001), hsCRP(*2.40vs.0.90 ; p<0.0001) and dyslipidemia(p<0.0001).No differences in systolic(*116.00 ; vs.118.00 ; p=0.57) and diastolic BP(*75.19±7.46vs.73.55±7.83 ; p=0.73), eGFR(*75.39 vs. 82.36 p=0.22), ACR(*3.95 vs. 3.28 p=0.22) and AP(6.95 vs. 11.72 p=0.51) were observed.Multiple regression analysis showed that AP is neither predictor of ACR(β=0.018, SE=0.29, p=0.95), alpha 1 microglobulin- creatinine(β=0.006, SE=0.02, p=0.82), eGFR(β=-0.08, SE=0.098, p=0.40)nor of systolic(β=0.05, SE=0.16, p=0.76) and diastolic BP(β=0.04, SE=0.13, p=0.76). *Values are expressed as median. Conclusions: Markers of metabolic syndrome and inflammation are presented in viscerally obese subjects.We failed to find relationship between AP and early signs of kidney damage in viscerally obese subjects after adjustment for risk factors.There was also no relationship between AP and BP.Further studies on large number and different populations are needed.

kidney damage ; adiponectin ; blood pressure

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