engleski

Phenyl-imidazolium and quinuclidinium oximes as antidotes against organophosporus and carbamate poisoning

The in vitro activity of human erythrocyte acetylcholinesterase (AChE) and protective activity against soman dichlorovos, and propoxur poisoning in male mice (in vivo experiments) were determined by using bis- phenyl imidazolium (2B) and imidazole- quinuclidinium oximes (BM-1). Oxime 2B strongly inhibits the AChE, and has a good reacitvation potency, but weak protective ability, against AChE inhibited by these agents. Oxime BM-1 inhibits weakly AChE and its in vitro activity against inhibited AChE is negligible. In vivo, this oxime is a very good protective agent against inhibitors tested in this paper. BM-1, given with atropine sulphate, provided a 100 % protection in male mice gainsit 4 x LD 50 soman, 11 x LD 50 dichlorovos, and 16 x LD 50 propoxur, respecitvely. The results indicate that in vivo effectiveness of quinuclidinium oxime is not related to its reactivatin or protective potentials for AChe, as shown by the in vitro experiments. The in vivo action of this BM-1 oxime must be attributed to mechanism not yet well defined.

quinuclidinium oxime ; AChE ; dichlorvos ; carbamates ; propoxur ; carbaryl ; soman

nije evidentirano