Napredna pretraga

Pregled bibliografske jedinice broj: 634

Phenyl-imidazolium and quinuclidinium oximes as antidotes against organophosphorus adn carbamate poisoning


Radić, Božica; Lucić, Ana; Primožič, Ines; Rončević, Renata; Binenfeld, Zlatko
Phenyl-imidazolium and quinuclidinium oximes as antidotes against organophosphorus adn carbamate poisoning // The Second Chemical and Biological Medical Tretment Symposium : proceedings / Price, Richard (ur.).
Spiez, Švicarska: ASA, Inc., 1997. str. 37-38 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
Phenyl-imidazolium and quinuclidinium oximes as antidotes against organophosphorus adn carbamate poisoning
(Phenyl-imidazolium and quinuclidinium oximes as antidotes against organophosporus and carbamate poisoning)

Autori
Radić, Božica ; Lucić, Ana ; Primožič, Ines ; Rončević, Renata ; Binenfeld, Zlatko

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
The Second Chemical and Biological Medical Tretment Symposium : proceedings / Price, Richard - Spiez, Švicarska : ASA, Inc., 1997, 37-38

Skup
Chemical and Biological Medical Tretment Symposium (2 ; 1996)

Mjesto i datum
Spiez, Švicarska, 07.-12.07.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Quinuclidinium oxime ; AChE ; dichlorvos ; carbamates ; propoxur ; carbaryl ; soman

Sažetak
The in vitro activity of human erythrocyte acetylcholinesterase (AChE) and protective activity against soman dichlorovos, and propoxur poisoning in male mice (in vivo experiments) were determined by using bis-phenyl imidazolium (2B) and imidazole-quinuclidinium oximes (BM-1). Oxime 2B strongly inhibits the AChE, and has a good reacitvation potency, but weak protective ability, against AChE inhibited by these agents. Oxime BM-1 inhibits weakly AChE and its in vitro activity against inhibited AChE is negligible. In vivo, this oxime is a very good protective agent against inhibitors tested in this paper. BM-1, given with atropine sulphate, provided a 100 % protection in male mice gainsit 4 x LD 50 soman, 11 x LD 50 dichlorovos, and 16 x LD 50 propoxur, respecitvely. The results indicate that in vivo effectiveness of quinuclidinium oxime is not related to its reactivatin or protective potentials for AChe, as shown by the in vitro experiments. The in vivo action of this BM-1 oxime must be attributed to mechanism not yet well defined.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
00220105

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb