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HLA-G polymorphisms and molecule function--questions and more questions--a review. (CROSBI ID 91451)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

van der Ven, Katrin ; Pfeiffer, K ; Škrablin, Snježana HLA-G polymorphisms and molecule function--questions and more questions--a review. Placenta, 21 (2000), Suppl A; 86-92-x

Podaci o odgovornosti

van der Ven, Katrin ; Pfeiffer, K ; Škrablin, Snježana

engleski

HLA-G polymorphisms and molecule function--questions and more questions--a review.

Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is predominantly expressed on invasive trophoblastic cells and is postulated to be a mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. The HLA-G protein exists in soluble and membrane-bound isoforms generated through alternative splicing. Although initially considered to be non-polymorphic, variations of the HLA-G DNA sequence have been reported which led to the definition of a limited number of HLA-G alleles including the Null-allele G*0105N. Whereas the HLA-G DNA sequence shows a high degree of conservation in positions which are essential for classical HLA-I molecule functions, polymorphic sites in HLA-G are not congruent with sites of high nucleotide variability in classical HLA. The identification of two females with recurrent spontaneous abortions who are homozygous for the G*0105N Null-allele re-opens the discussion about the role of HLA-G in pregnancy and underlines the need of a systematic analysis of the different hypotheses of HLA-G function in vivo.

HLA-G polymorphisms

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Podaci o izdanju

21 (Suppl A)

2000.

86-92-x

objavljeno

Povezanost rada

Kliničke medicinske znanosti