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Pregled bibliografske jedinice broj: 634112

Genetic polymorphism of INS, INSR and IRS-1 genes are not associated with polycystic ovary syndrome in Croatian women


Škrgatić, Lana; Pavičić Baldani, Dinka; Geršak, Ksenija; Černe, Jasmina Živa; Ferk, Polonca; Ćorić, Mario
Genetic polymorphism of INS, INSR and IRS-1 genes are not associated with polycystic ovary syndrome in Croatian women // Collegium antropologicum, 37 (2013), 1; 141-146 (međunarodna recenzija, članak, znanstveni)


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Naslov
Genetic polymorphism of INS, INSR and IRS-1 genes are not associated with polycystic ovary syndrome in Croatian women

Autori
Škrgatić, Lana ; Pavičić Baldani, Dinka ; Geršak, Ksenija ; Černe, Jasmina Živa ; Ferk, Polonca ; Ćorić, Mario

Izvornik
Collegium antropologicum (0350-6134) 37 (2013), 1; 141-146

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
polycystic ovary syndrome; VNTR INS; C/T INSR; Gly792Arg IRS-1; insulin resistance

Sažetak
Obesity and insulin resistance is a common finding in patients with polycystic ovary syndrome (PCOS). Significant number of PCOS women experience insulin resistance that is irrespective of the degree of obesity suggesting possible ge- netic basis. Therefore, several polymorphisms of the genes encoding for the insulin (INS), insulin receptor (INSR) or in- sulin receptor substrates (IRS) involved in postreceptor signaling have been explored for their association with abnormal sensitivity to insulin in PCOS. The aim of the present study was to determine whether selected polymorphisms of INS, INSR and IRS-1 are associated with the development of PCOS as well as with increased insulin resistance in Croatian women with PCOS. The study enrolled 150 women with PCOS and 175 control women. The diagnosis of PCOS was based on Rotterdam consensus criteria. Each subject underwent an evaluation of body mass index (BMI), hirsutism, acne and menstrual cycle abnormalities as well as follicular stimulating hormone (FSH), luteinizing hormone (LH), to- tal and free testosterone, androstendione, dehydroepiandrosterone sulphate (DHEAS), sex hormone binding globulin (SHBG), fasting glucose and fasting insulin. Insulin resistance (IR) was quantified using the homeostatic model assess- ment of IR (HOMA-IR). Molecular analyses for the genetic polymorphisms were preformed. There was a significant dif- ference in clinical and biochemical characteristics of the studied groups except for BMI and fasting glucose levels. No significant differences were observed in the genotype and allele distribution of the VNTR INS, C/T INSR, Gly792Arg IRS-1 polymorphisms between cases and controls. Moreover, no association was found between VNTR INS, C/T INSR and Gly792Arg IRS-1 polymorphism and parameters of insulin resistance in PCOS patients. In conclusion, our data does not support an association between VNTR INS, C/T INSR and Gly792Arg IRS-1 polymorphism and susceptibility to PCOS or insulin resistance in Croatian women with PCOS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-0388 - Etiologija i patogeneza PCOS - odabir terapije i metaboličke posljedice (Pavičić Baldani, Dinka, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

Hrčak

Citiraj ovu publikaciju:

Škrgatić, Lana; Pavičić Baldani, Dinka; Geršak, Ksenija; Černe, Jasmina Živa; Ferk, Polonca; Ćorić, Mario
Genetic polymorphism of INS, INSR and IRS-1 genes are not associated with polycystic ovary syndrome in Croatian women // Collegium antropologicum, 37 (2013), 1; 141-146 (međunarodna recenzija, članak, znanstveni)
Škrgatić, L., Pavičić Baldani, D., Geršak, K., Černe, J., Ferk, P. & Ćorić, M. (2013) Genetic polymorphism of INS, INSR and IRS-1 genes are not associated with polycystic ovary syndrome in Croatian women. Collegium antropologicum, 37 (1), 141-146.
@article{article, author = {\v{S}krgati\'{c}, Lana and Pavi\v{c}i\'{c} Baldani, Dinka and Ger\v{s}ak, Ksenija and \v{C}erne, Jasmina \v{Z}iva and Ferk, Polonca and \'{C}ori\'{c}, Mario}, year = {2013}, pages = {141-146}, keywords = {polycystic ovary syndrome, VNTR INS, C/T INSR, Gly792Arg IRS-1, insulin resistance}, journal = {Collegium antropologicum}, volume = {37}, number = {1}, issn = {0350-6134}, title = {Genetic polymorphism of INS, INSR and IRS-1 genes are not associated with polycystic ovary syndrome in Croatian women}, keyword = {polycystic ovary syndrome, VNTR INS, C/T INSR, Gly792Arg IRS-1, insulin resistance} }
@article{article, author = {\v{S}krgati\'{c}, Lana and Pavi\v{c}i\'{c} Baldani, Dinka and Ger\v{s}ak, Ksenija and \v{C}erne, Jasmina \v{Z}iva and Ferk, Polonca and \'{C}ori\'{c}, Mario}, year = {2013}, pages = {141-146}, keywords = {polycystic ovary syndrome, VNTR INS, C/T INSR, Gly792Arg IRS-1, insulin resistance}, journal = {Collegium antropologicum}, volume = {37}, number = {1}, issn = {0350-6134}, title = {Genetic polymorphism of INS, INSR and IRS-1 genes are not associated with polycystic ovary syndrome in Croatian women}, keyword = {polycystic ovary syndrome, VNTR INS, C/T INSR, Gly792Arg IRS-1, insulin resistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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