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Synthesis and characterization of imidazole - and benzimidazole-1-triflouroacetamides


Ramić, Alma; Primožič, Ines; Tomić-Pisarović, Srđanka
Synthesis and characterization of imidazole - and benzimidazole-1-triflouroacetamides // XXIII. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka = XXIII Croatian Meeting of Chemists and Chemical Engineers Book of Abstracts / Hadžiev, Andrea ; Blažeković, Zdenko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa ; Hrvatsko kemijsko društvo, 2013. str. 138-138 (poster, nije recenziran, sažetak, znanstveni)


Naslov
Synthesis and characterization of imidazole - and benzimidazole-1-triflouroacetamides

Autori
Ramić, Alma ; Primožič, Ines ; Tomić-Pisarović, Srđanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIII. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka = XXIII Croatian Meeting of Chemists and Chemical Engineers Book of Abstracts / Hadžiev, Andrea ; Blažeković, Zdenko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa ; Hrvatsko kemijsko društvo, 2013, 138-138

ISBN
978-953-6894-50-5

Skup
Hrvatski skup kemičara i kemijskih inženjera (23 ; 2013)

Mjesto i datum
Osijek, Hrvatska, 21.-24.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Trifluoroacetamides ; imidazole ; benzimidazole ; BChE

Sažetak
The trifluoromethyl group is important substituent in medicinal chemistry due to its unique stereoelectronic properties. Thus, introduction of trifluoroacetic group into imidazol- and benzimidazole will result in a changed reactivity of heteroaromatic moieties. Furthermore, presence of benzimidazole nucleus in a numerous categories of therapeutic agents has made it interesting scaffold for research of new therapeutic agents such as antivirals, antiparasites, antihypertensives, etc. A series of novel, differently substituted imidazol- and benzimidazole-1- triflouroacetamides have been prepared and characterized. Prepared compounds were nonsubstituted or phenyl (4- and 5- ; 2-, 4- and 5-) and 4, 5-dichloro substituted imidazole derivatives while benzimidazole-1- triflouroacetamides were non-substituted or 2-phenyl, 5-nitro and 5, 6-dimethyl substituted derivatives. Structural properties of the prepared compounds were studied by IR, 1H and 13C NMR spectroscopies. Since the inhibition of butyrylcholinesterase has become important target to treat Alzheimer disease, all prepared compounds were screened for inhibition on human, horse, rabbit and guinea pig serum butyrylcholinesterase activity using Ellman’s reagent. Kinetic studies showed that tested compounds were generally moderate inhibitors apart from imidazole-1- triflouroacetamide who did not show affinity toward the enzyme.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Prirodoslovno-matematički fakultet, Zagreb