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NOVI HETEROCIKLIČKI OKSIMI I NJIHOVA INTERAKCIJA S BUTIRILKOLINESTERAZAMA


Makarić, Sandro; Morasi Piperčić, Sara; Baumann, Krešimir; Primožič, Ines; Tomić-Pisarović, Srđanka
NOVI HETEROCIKLIČKI OKSIMI I NJIHOVA INTERAKCIJA S BUTIRILKOLINESTERAZAMA // Knjiga sažetaka (Book of Abstracts)
Osijek, Hrvatska, 2013. str. 137-137 (poster, domaća recenzija, sažetak, znanstveni)


Naslov
NOVI HETEROCIKLIČKI OKSIMI I NJIHOVA INTERAKCIJA S BUTIRILKOLINESTERAZAMA
(NOVEL HETEROCYCLIC OXIMES AND THEIR INTERACTIONS WITH BUTIRYLCHOLINESTERASES)

Autori
Makarić, Sandro ; Morasi Piperčić, Sara ; Baumann, Krešimir ; Primožič, Ines ; Tomić-Pisarović, Srđanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka (Book of Abstracts) / - Osijek, Hrvatska, 2013, 137-137

ISBN
978-953-6894-50-5

Skup
23. hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Osijek, Hrvatska, 21.-24.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Imidazole; benzimidazole; cholinesterase

Sažetak
Highly toxic acetylcholinesterase inhibiting pesticides, organophosphates (OP) and carbamates are intensively used troughout the world and continue to be responsible for poisoning and deaths.1, 2 Since there is still no single, broad-spectrum compound suitable for the antidotal treatment of poisoning with all OP agents a series of novel aliphatic and aromatic quaternary salts of N-alkyl/aryl imidazol- and benzimidazole-2-aldoximes have been prepared as potential reactivators of inhibited butyrylcholinesterase. N-alkylations were carried out with the appropriate electrophile in 50% aqeous NaOH and small amount of DMSO to assure better dissolving for reagents. N-alkyl/aryl azoles were converted to the appropriate 2-carbaldehydes by using modified Ivesen-Lund method3 and then to 2-aldoximes. Reaction with the alkyl/aryl halogenides resulted in a desired quaternary salts. Inhibitory properties of prepared compounds and their reactivation efficiency of Paraoxon inhibited human butyrylcholinesterase as well as horse, rabbit and guinea pig serum will be tested. Structural characteristics of an efficient oxime reactivator will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Prirodoslovno-matematički fakultet, Zagreb