engleski

Non Hodgkin lymphoma of the urinary bladder

Lymphomas arising in the urinary tract and male genital organs account for less than 5% of extranodal lymphomas. Lymphomas of the bladder represent approximately 0.2% of the primary neoplastic lesions. The incidence of secondary involvement of the urinary bladder in lymphoma/leukemia is 10%-20%. The majority of bladder lymphomas are marginal zone lymphomas of mucosa-associated lymphoid tissue. A 46-year-old male patient presented with hematuria and flank pain. Computed tomography scan and intravenous urography revealed a 12 tumor mass in the urinary bladder. Transurethral resection was performed. Three samples of bladder wall were sent for histopathologic analysis. Histologically, all samples were covered with urothelium showing reactive atypia with cystically dilated von Brunn’s nests, suggesting the diagnosis of cystitis cystica. Lamina propria and muscular layer were diffusely infiltrated with numerous small- to medium-sized uniform cells, showing abundant mitotic activity (3/HPF). Some larger cells with vesicular nucleus and peripherally set nucleolus were found in-between. These cells were immunohistochemically positive for CD 20 and bcl- 2, while other markers were negative (bcl-6, CD 5, CD 3, CD 10). Proliferative activity measured immunohistochemically with Ki-67 was up to 5%. Based on the clinical data, histology and immunohistochemical profile, the diagnosis of primary B-phenotype non-Hodgkin's lymphoma of the urinary bladder was made. One year after chemotherapy treatment, the patient is well, without any signs of recurrence. In conclusion, primary lymphomas of the bladder are rare, as opposed to secondary involvement in advanced stages of systemic disease, which is rather common. Mucosa associated lymphoid tissue (MALT) lymphoma is the most common primary lymphoma involving the bladder. The prognosis of this type of lymphoma is good, with extremely low mortality rates.

lymphoma; urinary bladder

nije evidentirano