engleski

External and internal radiomorphologic features in lung cancer

AIM: To determine which radiomorphologic features of tumors ; size, edges and structure obtained from computed tomography (CT) denote non-small cell lung cancer (NSCLC). The measured parameters are compared to levels of tumor marker CYFRA 21-1 in patients' blood. METHODS: The retrospective analysis includes 445 subjects ; 347 NSCLC patients, 79 lung metastasis and 19 benign cysts. The blood samples were taken before surgical treatment. The computed tomography was performed using the instrument series SCT- 7800T by Shimadzu Corporation (Japan) in Clinical Department of Diagnostic and Interventional Radiology, University Hospital Centre Zagreb. The determination of blood levels of CYFRA 21-1 has been performed on fully automated instrument Elecsys 2010 (Roche Diagnostics, Switzerland) in Clinical Unit for Molecular Biology and Genetics of Tumors, Clinic for Pulmonary Diseases Jordanovac, University Hospital Centre Zagreb. RESULTS: Unlike metastasis and cyst group, the level of CYFRA 21-1 positively correlates with the greatest measured diameter of NSCLC (r=0, 2051, p=0, 0001). In comparison of various edges in all the subjects the highest values of CYFRA 21-1 were seen in spiculated and lobulated, poorly-defined edges with significant differences between all edges (p=0, 0001). The inhomogeneous structure of lesion has presented the highest values of CYFRA 21-1 and implies primary NSCLC. CONCLUSION: The greater diameter of lesion as well as spiculated, lobulated and poorly defined edges, and inhomogeneous structure point to malignant phenotype, above all primary NSCLC. Such radiomorphologic features cause the greatest release of CYFRA 21-1 in circulation.

Computed tomography; radiomorphology; lung cancer; tumor marker

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