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Pregled bibliografske jedinice broj: 631571

Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults


Nikolac Perković, Matea; Mustapić, Maja; Pavlović, Mladen; Uzun, Suzana; Kozumplik, Oliver; Barišić, Ivan; Muck-Šeler, Dorotea; Pivac, Nela
Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults // Neuroscience letters, 545 (2013), 127-131 doi:10.1016/j.neulet.2013.04.036 (međunarodna recenzija, članak, znanstveni)


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Naslov
Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults

Autori
Nikolac Perković, Matea ; Mustapić, Maja ; Pavlović, Mladen ; Uzun, Suzana ; Kozumplik, Oliver ; Barišić, Ivan ; Muck-Šeler, Dorotea ; Pivac, Nela

Izvornik
Neuroscience letters (0304-3940) 545 (2013); 127-131

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Brain-derived neurotrophic factor; Val66Met polymorphism; Body mass index; Healthy subjects; Weight change over time

Sažetak
Obesity is becoming the epidemic health problem worldwide with a very complex etiology. The interaction between diverse genetic and environmental factors contributes to development of obesity. Among myriad of functions in central and peripheral tissues, brain-derived neurotrophic factor (BDNF) also regulates energy homeostasis, food intake and feeding behavior, and has a role in obesity and increased body mass index (BMI). BDNF Val66Met (rs6265) polymorphism is associated with BMI gain, but both positive associations and non-replications are reported. Since BMI changes over time and since genetic influences on BMI vary with age, the aim of the study was to evaluate association between BDNF Val66Met polymorphism and BMI gain in healthy subjects with middle or old age. The study included a cohort of 339 adult healthy Caucasians of Croatian origin, free of eating and metabolic disorders, evaluated in three time periods in the year 1972, 1982 and 2006, when the subjects were around 40, 50 and 70 years old, respectively. The results revealed a significant effect of smoking on BMI, but a lack of significant association between BDNF Val66Met polymorphism and overweight or obesity, and no significant association between BDNF Val66Met and BMI changes over time. These results did not confirm the major role of BDNF Val66Met in the regulation of BMI changes in adult and old healthy subjects.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( POIROT)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( POIROT)
108-1083509-3511 - Nuspojave psihofarmaka u bolesnika s psihotičnim i afektivnim poremećajima (Uzun, Suzana, MZOS ) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi dx.doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Nikolac Perković, Matea; Mustapić, Maja; Pavlović, Mladen; Uzun, Suzana; Kozumplik, Oliver; Barišić, Ivan; Muck-Šeler, Dorotea; Pivac, Nela
Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults // Neuroscience letters, 545 (2013), 127-131 doi:10.1016/j.neulet.2013.04.036 (međunarodna recenzija, članak, znanstveni)
Nikolac Perković, M., Mustapić, M., Pavlović, M., Uzun, S., Kozumplik, O., Barišić, I., Muck-Šeler, D. & Pivac, N. (2013) Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults. Neuroscience letters, 545, 127-131 doi:10.1016/j.neulet.2013.04.036.
@article{article, year = {2013}, pages = {127-131}, DOI = {10.1016/j.neulet.2013.04.036}, keywords = {Brain-derived neurotrophic factor, Val66Met polymorphism, Body mass index, Healthy subjects, Weight change over time}, journal = {Neuroscience letters}, doi = {10.1016/j.neulet.2013.04.036}, volume = {545}, issn = {0304-3940}, title = {Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults}, keyword = {Brain-derived neurotrophic factor, Val66Met polymorphism, Body mass index, Healthy subjects, Weight change over time} }
@article{article, year = {2013}, pages = {127-131}, DOI = {10.1016/j.neulet.2013.04.036}, keywords = {Brain-derived neurotrophic factor, Val66Met polymorphism, Body mass index, Healthy subjects, Weight change over time}, journal = {Neuroscience letters}, doi = {10.1016/j.neulet.2013.04.036}, volume = {545}, issn = {0304-3940}, title = {Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults}, keyword = {Brain-derived neurotrophic factor, Val66Met polymorphism, Body mass index, Healthy subjects, Weight change over time} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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