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Pregled bibliografske jedinice broj: 630394

Characterisation of macrolide-resistant pneumococcal strains in Zagreb region.


Vraneš, Jasmina; Bedenić, Branka; Knežević, Jasna; Jarža Davila, Neda; Škrinjarić, Alenka
Characterisation of macrolide-resistant pneumococcal strains in Zagreb region. // Abstracts of the 23rd European Congress of Clinical Microbiology and Infectious Diseases
Berlin, Njemačka, 2013. (ostalo, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 630394 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Characterisation of macrolide-resistant pneumococcal strains in Zagreb region.

Autori
Vraneš, Jasmina ; Bedenić, Branka ; Knežević, Jasna ; Jarža Davila, Neda ; Škrinjarić, Alenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 23rd European Congress of Clinical Microbiology and Infectious Diseases / - , 2013

Skup
23. Europski kongres kliničke mikrobiologije i infektivnih bolesti

Mjesto i datum
Berlin, Njemačka, 27-30.04.2013

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Streptococcus pneumoniae; antibiotics; macrolide resistance

Sažetak
Objectives: Increase in pneumococcal resistance to macrolides is particularly high in Croatia in the last years. Macrolide resistance in Zagreb region raised significantly from 25% in 2005 to 40% in 2008, and the same increase was detected two years later in other parts of country as well. The aim of this study was to characterize macrolide-resistant strains from Zagreb region in dependence of their phenotypic traits. Methods: A total of 93 macrolide-resistant Streptococcus pneumoniae strains were obtained in two-month period from nasopharyngeal swabs collected from 634 children aged 1-15 with a mean age of three years. Minimal inhibitory concentrations was determined for penicillin G, amoxicillin, ceftriaxone, cefuroxime, meropenem, erythromycin, azithromycin and clarithromycin, and serotyping of the strains was carried out by latex agglutination and Neufeld quellung test. Double-disk test (erythromycin + clindamycin) was used for characterization of resistant phenotype of macrolide-resistant strains. Results: The co-resistance to penicillin was determined in 31 (33.3%) strains with a 12.9% of highly resistant S. pneumoniae isolates (MIC range 2-4 mcg/ml). The resistance to other beta-lactams was lower with less than 10% of non-susceptibility to ceftriaxone and only 6.4% isolates intermediately resistant to amoxicillin. Macrolides showed decreased activity against tested strains, with resistance being 38.7%, 36.6% and 33.3% for erythromycin, azithromycin and clarithromycin, respectively. MIC90 of azithromycin and clarithromycin was 512 mcg/ml, while MIC90 for erythromycin was 1024 mcg/ml. The most common serotypes were 19F, and other serotypes (1, 2, 3, 4, 5, 8, 6A, 6B, 6C, 7, 8, 9, 10, 11, 14, 15, 17, 18C, 19A, 19C and 23F) were detected with a low frequency. Constitutive MLSB phenotype was predominant and Mphenotype was detected in 17.1% of the resistant strains. Conclusion: In contrast to other parts of country where prevalence of serotype 19A is the most higher, the macrolide-resistance in S. pneumoniae nasopharyngeal isolates collected in Zagreb region was associated with serotype 19F. Continued surveillance is necessary, and further studies are needed in order to detect emerging serotypes and multidrug resistant clones. The results of present study suggest the possibility of clonal dissemination of macrolide-resistant pneumococcal strains harbouring both erm (B) and mef (E) genes in Zagreb region.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080114-0306 - Djelovanje antibiotika na uzročnike biofilm infekcija
108-1080114-0015 - Mehanizmi rezistencije na antibiotike u Gram-negativnih bakterija (Bedenić, Branka, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Zdravstveno veleučilište, Zagreb


Citiraj ovu publikaciju

Vraneš, Jasmina; Bedenić, Branka; Knežević, Jasna; Jarža Davila, Neda; Škrinjarić, Alenka
Characterisation of macrolide-resistant pneumococcal strains in Zagreb region. // Abstracts of the 23rd European Congress of Clinical Microbiology and Infectious Diseases
Berlin, Njemačka, 2013. (ostalo, međunarodna recenzija, sažetak, znanstveni)
Vraneš, J., Bedenić, B., Knežević, J., Jarža Davila, N. & Škrinjarić, A. (2013) Characterisation of macrolide-resistant pneumococcal strains in Zagreb region.. U: Abstracts of the 23rd European Congress of Clinical Microbiology and Infectious Diseases.
@article{article, year = {2013}, keywords = {Streptococcus pneumoniae, antibiotics, macrolide resistance}, title = {Characterisation of macrolide-resistant pneumococcal strains in Zagreb region.}, keyword = {Streptococcus pneumoniae, antibiotics, macrolide resistance}, publisherplace = {Berlin, Njema\v{c}ka} }
@article{article, year = {2013}, keywords = {Streptococcus pneumoniae, antibiotics, macrolide resistance}, title = {Characterisation of macrolide-resistant pneumococcal strains in Zagreb region.}, keyword = {Streptococcus pneumoniae, antibiotics, macrolide resistance}, publisherplace = {Berlin, Njema\v{c}ka} }




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