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Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy (CROSBI ID 193119)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bierhaus, Angelika ; ... ; Lukić, Ivan Krešimir ; ... ; Nawroth, Peter P. Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy // Nature medicine, 18 (2012), 6; 926-933. doi: 10.1038/nm.2750

Podaci o odgovornosti

Bierhaus, Angelika ; ... ; Lukić, Ivan Krešimir ; ... ; Nawroth, Peter P.

engleski

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

This study establishes a mechanism for metabolic hyperalgesia based on the glycolytic metabolite methylglyoxal. We found that concentrations of plasma methylglyoxal above 600 nM discriminate between diabetes-affected individuals with pain and those without pain. Methylglyoxal depolarizes sensory neurons and induces post-translational modifications of the voltage-gated sodium channel Na(v)1.8, which are associated with increased electrical excitability and facilitated firing of nociceptive neurons, whereas it promotes the slow inactivation of Na(v)1.7. In mice, treatment with methylglyoxal reduces nerve conduction velocity, facilitates neurosecretion of calcitonin gene-related peptide, increases cyclooxygenase-2 (COX-2) expression and evokes thermal and mechanical hyperalgesia. This hyperalgesia is reflected by increased blood flow in brain regions that are involved in pain processing. We also found similar changes in streptozotocin-induced and genetic mouse models of diabetes but not in Na(v)1.8 knockout (Scn10(-/-)) mice. Several strategies that include a methylglyoxal scavenger are effective in reducing methylglyoxal- and diabetes-induced hyperalgesia. This previously undescribed concept of metabolically driven hyperalgesia provides a new basis for the design of therapeutic interventions for painful diabetic neuropathy.

methylglyoxal; Nav1.8; nociceptive neuron; hyperalgesia; diabetic neuropathy

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Podaci o izdanju

18 (6)

2012.

926-933

objavljeno

1078-8956

10.1038/nm.2750

Povezanost rada

Kliničke medicinske znanosti

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