Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion (CROSBI ID 193092)
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Schmidt, Daniel ; Bihr, Timo ; Seifert, Udo ; Smith, Ana-Sunčana
engleski
Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion
We analyze the stability of micro-domains of ligand-receptor bonds that mediate the adhesion of biological model membranes. After evaluating the effects of membrane fluctuations on the binding affinity of a single bond, we characterize the organization of bonds within the domains by theoretical means. In a large range of parameters, we find the commonly suggested dense packing to be separated by a free energy barrier from a regime in which bonds are sparsely distributed. If bonds are mobile, a coexistence of the two regimes should emerge, which agrees with recent experimental observations.
membrane ; adhesion
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