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Nucleation of Ligand-Receptor Domains in Membrane Adhesion


Bihr, T.; Seifert, Davor; Smith, Ana-Sunčana
Nucleation of Ligand-Receptor Domains in Membrane Adhesion // Physical review letters, 109 (2012), 25; 258101, 5 doi:10.1103/PhysRevLett.109.258101 (međunarodna recenzija, članak, znanstveni)


Naslov
Nucleation of Ligand-Receptor Domains in Membrane Adhesion

Autori
Bihr, T. ; Seifert, Davor ; Smith, Ana-Sunčana

Izvornik
Physical review letters (0031-9007) 109 (2012), 25; 258101, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Membranes ; fluctuations ; nucleation

Sažetak
We present a comprehensive model for the nucleation of domains in membrane adhesion. We determine the critical number of bonds in a nucleus and calculate the probability distribution of nucleation time from a discrete master equation. The latter is characterized by only four effective rates, which account for cooperative effects between bonds. We validate our model by finding excellent agreement with extensive Langevin simulations. In the range of parameters typical for cell adhesion, we find the critical number of bonds to be small. Furthermore, we find a characteristic separation between the bonds at which nucleation is particularly fast, pointing to potential regulatory mechanisms that could be used to control the cell recognition processes.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA


Projekt / tema
098-1191344-2860 - Proučavanje biomakromolekula računalnim metodama i razvoj novih algoritama (Sanja Tomić, )

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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