Nucleation of Ligand-Receptor Domains in Membrane Adhesion (CROSBI ID 193089)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Bihr, T. ; Seifert, Davor ; Smith, Ana-Sunčana
engleski
Nucleation of Ligand-Receptor Domains in Membrane Adhesion
We present a comprehensive model for the nucleation of domains in membrane adhesion. We determine the critical number of bonds in a nucleus and calculate the probability distribution of nucleation time from a discrete master equation. The latter is characterized by only four effective rates, which account for cooperative effects between bonds. We validate our model by finding excellent agreement with extensive Langevin simulations. In the range of parameters typical for cell adhesion, we find the critical number of bonds to be small. Furthermore, we find a characteristic separation between the bonds at which nucleation is particularly fast, pointing to potential regulatory mechanisms that could be used to control the cell recognition processes.
membranes ; fluctuations ; nucleation
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Podaci o izdanju
109 (25)
2012.
258101
5
objavljeno
0031-9007
1079-7114
10.1103/PhysRevLett.109.258101