Napredna pretraga

Pregled bibliografske jedinice broj: 629441

Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes


Cvija, Hrvoje; Kovačić, Nataša; Katavić, Vedran; Ivčević, Sanja; Aguila, Hector; Marušić, Ana; Grčević, Danka
Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes // Inflammation, 35 (2012), 5; 1618-1631 doi:10.1007/s10753-012-9477-y (međunarodna recenzija, članak, znanstveni)


Naslov
Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes

Autori
Cvija, Hrvoje ; Kovačić, Nataša ; Katavić, Vedran ; Ivčević, Sanja ; Aguila, Hector ; Marušić, Ana ; Grčević, Danka

Izvornik
Inflammation (0360-3997) 35 (2012), 5; 1618-1631

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone cells; endotoxin-stimulated lymphocytes

Sažetak
In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblasts (OBL) and osteoclasts (OCL), and of bone cells to modulate cytokine and activation profile of endotoxin- stimulated lymphocytes were tested. LPS-pulsed lymphocytes enhanced OCL but inhibited OBL differentiation and increased the RANKL/OPG ratio, and, at the same time, upregulated chemotactic properties of bone cells, specifically CCL2, CCL5, and CXCL10 in OCL and CCL5 and CXCL13 in OBL. In parallel, bone cells had immunosuppressive effects by downregulating the lymphocyte expression of interleukin (IL)-1, IL-6, TNF-α and co-stimulatory molecules. OCL stimulated the production of osteoclastogenic cytokine RANKL in T lymphocytes. The anti-inflammatory effect, especially of OBL, suggests a possible compensatory mechanism to limit the inflammatory reaction during infection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1080229-0140 - Molekularne interakcije koštanog i imunološkog sustava (Ana Marušić, )
108-1080229-0142 - Molekularni mehanizmi učinaka imunosnih poremećaja na kost (Danka Grčević, )
108-1080229-0341 - B limfociti, makrofagi i podrijetlo osteoklasta (Vedran Katavić, )

Ustanove
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split

Citiraj ovu publikaciju

Cvija, Hrvoje; Kovačić, Nataša; Katavić, Vedran; Ivčević, Sanja; Aguila, Hector; Marušić, Ana; Grčević, Danka
Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes // Inflammation, 35 (2012), 5; 1618-1631 doi:10.1007/s10753-012-9477-y (međunarodna recenzija, članak, znanstveni)
Cvija, H., Kovačić, N., Katavić, V., Ivčević, S., Aguila, H., Marušić, A. & Grčević, D. (2012) Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes. Inflammation, 35 (5), 1618-1631 doi:10.1007/s10753-012-9477-y.
@article{article, year = {2012}, pages = {1618-1631}, DOI = {10.1007/s10753-012-9477-y}, keywords = {bone cells, endotoxin-stimulated lymphocytes}, journal = {Inflammation}, doi = {10.1007/s10753-012-9477-y}, volume = {35}, number = {5}, issn = {0360-3997}, title = {Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes}, keyword = {bone cells, endotoxin-stimulated lymphocytes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


Citati