Dependence of cerebrospinal fluid pressure and volume on the changes of serum osmolarity in cats (CROSBI ID 192667)
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Podaci o odgovornosti
Jurjević, Ivana ; Maraković, Jurica ; Chudy, Darko ; Klarica, Marijan ; Froebe, Ana ; Orešković, Darko
engleski
Dependence of cerebrospinal fluid pressure and volume on the changes of serum osmolarity in cats
Objectives were to study the effect of blood osmolarity on cerebrospinal fluid (CSF) volume and CSF pressure in cats. Three types of methods were used on anesthetized cats. The first, ventriculo-cisternal perfusion (12.96 m L/ min) before and after i.v. application of 20% mannitol ; the second, measuring the outflow of CSF by cisternal free drainage ; and the third, measuring CSF pressure in the ventricles of an intact CSF system, with the second and third method being performed before and after the i.p. application of a hypo-osmolar substance (distilled water). n the first group, the application of 20% mannitol led to a significantly reduced ( p < 0.005) outflow volume (from 12.60 ± 0.29 to 0.94 ± 0.09 m L/min). In the second group, the outflow CSF volume significantly increased ( p < 0.001) after the application of distilled water (from 18.8 ± 0.3 to 28.2 ± 0.7 m L/min). In the third group, after the application of distilled water, the CSF pressure also significantly increased ( p < 0.05 ; from 8.3 ± 0.8 to 16.1 ± 0.14 cm H 2 O). We conclude that changes in serum osmolarity change the CSF volume because of the osmotic gradient between the blood and all of the CSF compartments, and also that the change in CSF pressure is closely associated with changes in CSF volume.
Cat ; Central nervous system ; Cerebrospinal fluid ; Cerebrospinal fl uid hydrodynamics ; Cerebrospinal fluid pressure ; Cerebrospinal fluid volume ; Blood osmolarity
Intracranial Pressure and Brain Monitoring XIV ; Martin U. Schuhmann, Marek Czosnyka (ur.). ; ISBN 978-3-7091-0956-4.
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Veterinarska medicina