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Pregled bibliografske jedinice broj: 627601

Comparative study of o-, m- and p- substituted N-methylpyridinium aldoximes and their reactions with the aquapentacyanoferrate(II) ion


Damjanović, Vladimir; Cvijanović, Danijela; Lovrić, Jasna; Matković-Čalogović, Dubravka; Foretić, Blaženka
Comparative study of o-, m- and p- substituted N-methylpyridinium aldoximes and their reactions with the aquapentacyanoferrate(II) ion // XXIII. Hrvatski skup kemičara i kemijskih inženjera-Knjiga sažetaka / Hadžiev, Andrea ; Blažeković, Zdenko (ur.) (ur.).
Zagreb: Hrvatsko kemijsko društvo/Hrvatsko društvo kemijskih inženjera i tehnologa, 2013. str. 108-108 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 627601 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Comparative study of o-, m- and p- substituted N-methylpyridinium aldoximes and their reactions with the aquapentacyanoferrate(II) ion

Autori
Damjanović, Vladimir ; Cvijanović, Danijela ; Lovrić, Jasna ; Matković-Čalogović, Dubravka ; Foretić, Blaženka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIII. Hrvatski skup kemičara i kemijskih inženjera-Knjiga sažetaka / Hadžiev, Andrea ; Blažeković, Zdenko (ur.) - Zagreb : Hrvatsko kemijsko društvo/Hrvatsko društvo kemijskih inženjera i tehnologa, 2013, 108-108

ISBN
978-953-6894-50-5

Skup
XXIII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Osijek, Hrvatska, 21.-24.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
N-methylpyridinium aldoximes and their pentacyanoferrate(II) complexes

Sažetak
Biological importance of pyridinum aldoximes is closely related to their structure, acidic properties, nuchleophilicity and coordination ability. Compounds of pyridinium aldoxime type have been shown to exhibit a great variety of pharmacological effects. An important pharmacological application is derived from their capability to reactivate organophosphate-inactivated acethylcholinesterase. N-methylpyridinium-2-aldoxime chloride (PAM2-Cl), N-methylpyridinium-3-aldoxime iodide (PAM3-I) and N-methylpyridinium-4-aldoxime iodide (PAM4-I) were used to explore the influence of the position of the aldoxime group in N-methylpyridinium ring on the structure, chemical properties and reactivity toward the pentacyanoferrate(II) moiety. Aquapentacyanoferrate(II) ion, an useful model for biological macromolecules with a labile sixth coordination site, was used as a metal reagent. Crystal structure characterization was done for PAM3-I and compared with the known structures of PAM4-I and PAM2-Cl. Ionization ability for all three ligands was determined and was found to be in good agreement with their structural differences and consequent resonance stabilization of their aldoximato forms. Reactions of the examined ligands with the aquapentacyanoferrate(II) ion were studied in buffered aqueous media by UV/Vis spectroscopy. Comparative kinetic and equilibrium studies on the formation and dissociation of the produced pentacyano(ligand)ferrate(II) complexes were carried out at 25°C and I=0.1 M. Equilibrium constants and stoichiometry of the complexes at pH 6 were determined by mole ratio method. The kinetic properties of the produced complexes were determined in a pH range 5.0-11.5 and correlated with σ-donor and π-acceptor capability of the ligands. Furthermore, the pH-dependency of the complex dissociation rate was analyzed in terms of ionization ability of the coordinated ligand. The obtained values for the equilibrium constants, identified as apparent formation constants, along with the kinetic parameters suggested that all three complexes can be classified as instable and labile.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
108-1193079-3070 - Kompleksi željeza i biološki aktivnih liganada (Foretić, Blaženka, MZOS ) ( CroRIS)
119-1193079-1084 - Strukturno istraživanje bioloških makromolekula metodom rentgenske difrakcije (Matković-Čalogović, Dubravka, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb


Citiraj ovu publikaciju:

Damjanović, Vladimir; Cvijanović, Danijela; Lovrić, Jasna; Matković-Čalogović, Dubravka; Foretić, Blaženka
Comparative study of o-, m- and p- substituted N-methylpyridinium aldoximes and their reactions with the aquapentacyanoferrate(II) ion // XXIII. Hrvatski skup kemičara i kemijskih inženjera-Knjiga sažetaka / Hadžiev, Andrea ; Blažeković, Zdenko (ur.) (ur.).
Zagreb: Hrvatsko kemijsko društvo/Hrvatsko društvo kemijskih inženjera i tehnologa, 2013. str. 108-108 (poster, nije recenziran, sažetak, znanstveni)
Damjanović, V., Cvijanović, D., Lovrić, J., Matković-Čalogović, D. & Foretić, B. (2013) Comparative study of o-, m- and p- substituted N-methylpyridinium aldoximes and their reactions with the aquapentacyanoferrate(II) ion. U: Hadžiev, A. & Blažeković, Z. (ur.)XXIII. Hrvatski skup kemičara i kemijskih inženjera-Knjiga sažetaka.
@article{article, author = {Damjanovi\'{c}, Vladimir and Cvijanovi\'{c}, Danijela and Lovri\'{c}, Jasna and Matkovi\'{c}-\v{C}alogovi\'{c}, Dubravka and Foreti\'{c}, Bla\v{z}enka}, year = {2013}, pages = {108-108}, keywords = {N-methylpyridinium aldoximes and their pentacyanoferrate(II) complexes}, isbn = {978-953-6894-50-5}, title = {Comparative study of o-, m- and p- substituted N-methylpyridinium aldoximes and their reactions with the aquapentacyanoferrate(II) ion}, keyword = {N-methylpyridinium aldoximes and their pentacyanoferrate(II) complexes}, publisher = {Hrvatsko kemijsko dru\v{s}tvo/Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa}, publisherplace = {Osijek, Hrvatska} }
@article{article, author = {Damjanovi\'{c}, Vladimir and Cvijanovi\'{c}, Danijela and Lovri\'{c}, Jasna and Matkovi\'{c}-\v{C}alogovi\'{c}, Dubravka and Foreti\'{c}, Bla\v{z}enka}, year = {2013}, pages = {108-108}, keywords = {N-methylpyridinium aldoximes and their pentacyanoferrate(II) complexes}, isbn = {978-953-6894-50-5}, title = {Comparative study of o-, m- and p- substituted N-methylpyridinium aldoximes and their reactions with the aquapentacyanoferrate(II) ion}, keyword = {N-methylpyridinium aldoximes and their pentacyanoferrate(II) complexes}, publisher = {Hrvatsko kemijsko dru\v{s}tvo/Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa}, publisherplace = {Osijek, Hrvatska} }




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