engleski

Osteoporosis and kidney impairment in postmenopausal women

Background: Both osteoporosis and kidney impairment become more prevalent with age. The aim of this study was to investigate the prevalence of compromised kidney function in women with osteopenia and osteoporosis, and to assess the agreement between GFR estimated with creatinine clearance (CrCl) and the Cockcroft-Gault equation (CG). Materials and methods: We studied postmenopausal women, divided according to T-scores into two groups: normal/osteopenic and osteoporotic. They were further divided, using CrCl and CG, into groups depending on chronic kidney disease. Serum calcium, phosphorus and creatinine, and 24hour-urine calcium and creatinine were determined. Estimated GFRs were calculated using the CrCl and CG. Informations about age, height, weight were collected. Results: 190 postmenopausal women (median age 67(45-88) years) were divided into subgroups: normal/osteopenia (N=143 ; 75%) and osteoporosis (N=47 ; 25%). Differences were found comparing age, weight, urine creatinine and eGFR with the CG. The prevalence of kidney impairment (GFR < 60 mL/min/1.73 m2) according to CrCl and CG in normal/osteopenic women was 17% and 19%, respectively ; and in the osteoporosis group 34% and 36%, respectively. The prevalence was higher in the osteoporosis group (P=0.029 for CrCl ; P=0.025 for CG). Weighted kappa between CrCl and CG was 0.500, 0.483 and 0.487 in the overall, normal/osteopenia and osteoporosis subgroup, respectively. Conclusions: Our results showed substantial prevalence of kidney impairment in postmenopausal women with osteoporosis. This must be taken into account when considering the prescription of medications with kidney clearance. The kappa statistics classified the agreement between CrCl and CG as moderate.

Osteoporosis; kidney impairment; postmenopausal women

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