Lipid profile in patients with chronic obstructive pulmonary disease (CROSBI ID 596375)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Milevoj Kopčinović, Lara ; Pancirov, Dolores ; Simić, Laur ; Čepelak, Ivana ; Žanić Grubišić, Tihana ; Rumora, Lada
engleski
Lipid profile in patients with chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a complex systemic disease associated with many comorbidities. Cardiovascular diseases (CVD) are the leading cause of death among patients with COPD. Our aim was to assess the lipid profile and the relationship between lipid and lung function parameters in COPD patients. The study included 38 healthy subjects (15 smokers, 10 ex-smokers, 13 non-smokers) and 103 COPD patients (31 smokers, 25 ex-smokers, 47 non-smokers). COPD patients were also subdivided according to disease severity (GOLD stages II-IV). FEV1 predicted and FEV1/FVC were determined by spirometry. Total cholesterol, triglycerides, HDL cholesterol, ApoA and ApoB were measured in sera of all participants, while LDL cholesterol and LDL/HDL and ApoB/ApoA ratios were calculated. Total cholesterol, triglycerides, LDL cholesterol and ApoA were lower, and ApoB/ApoA ratio was higher in patients with COPD (P=0.003, P<0.001, P=0.043, P<0.001, P=0.005, respectively). No differences were found in HDL cholesterol and ApoB concentrations and LDL/HDL ratio when comparing patients with healthy subjects. However, HDL was weakly negatively correlated with FEV1/FVC in the patient group (r= -0.27, P=0.006). In addition, neither disease severity nor smoking status influenced lipid parameters in COPD patients. Although COPD is associated with an increased risk of CVD, our results do not confirm a pro-atherogenic lipid pattern in these patients. However, further research including a larger number of participants is needed to clarify this dilemma.
lipid profile; COPD
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Podaci o prilogu
A146-A147.
2012.
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objavljeno
Podaci o matičnoj publikaciji
Biochemia medica
1330-0962
Podaci o skupu
2nd European Joint Congress of EFLM and UEMS (2 ; 2012) ; Congress of the Croatian Society for Medical Biochemistry and Laboratory medicine : Laboratory Medicine at the Clinical Interface (7 ; 2012)
poster
10.10.2012-13.10.2012
Dubrovnik, Hrvatska