engleski

Cellular antigen stimulation test (CAST) in the evaluation of drug hypersensitivity

In the present study, diagnostic value of the skin tratch test (SCR), lymphocyte transformation test (LTT) and cellular antigen stimulation test (CAST) in confirming drug hypersensitivity was compaared. A group of 61 patients with clinical manifestations of allergic reactions such as urticaria medicamentosa, angioneurotic edema, anaphylaxis, medicamentous exanthema and allergic dermaatitis were included in study. Hypersensitivity reaction to an analgesic (aspirin) was detected in 15, to antibiotics in 38 (19 to penicillin G and V, 11 to amoxicillin and 8 to cephalosporin C) and to chemoterapeutic (trimethoprim/sulfamethoxazole) in 8 patients. Positive scratch test was recorded in 42% (5/12), LTT in 36 % (4/11), and CAST to aspirin in 43% (6/14) of the patients. Positive LTT to penicillin G and V was found in 10% (2/19) and positive CAST in 5% of the patients. All patients (2/2) had positive to SCR to chemotherapeutic whereas 38% (3/8) had positive LTT and 38% (3/8) positive CAST. Our results showed that the diagnostic sensitivity of CAST was not substantially superior to SCR and LTT in werifying various types of drug hypersensitivity.

drug hypersensitivity; scratch test; lymphocyte transformation test; cellular antigen stimulation test

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