engleski

Structure of novel mannoconjugates with heterocyclic oximes and their interaction with acetylcholinesterase

In the attempt to improve the quality of antidotes against organophosphorus poisoning, heterocyclic oxime reactivators of inhibited AChE were linked to the sugar moiety. It was found that the attachement of a glucose to the oxime derivative increases the bioavailability of the antidote because they can mor easily cross blood-brain barrier and the antidote is retained longer in the blood circulation. Moreover, sugar analogs are in principle less toxic than the non-sugar analogs.

antidotes ; mannoconjugates ; oximes ; AChE

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