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Structure of novel mannoconjugates with heterocyclic oximes and their interaction with acetylcholinesterase


Primožič, Ines; Baumann, Krešimir; Tomić-Pisarović, Srđanka
Structure of novel mannoconjugates with heterocyclic oximes and their interaction with acetylcholinesterase // 13th Medical Chemical Defence Conference 2011 : Current Status of Terapeutic Approaches to Nerve Agent Poisoning
München, Njemačka, 2011. str. 47-47 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Structure of novel mannoconjugates with heterocyclic oximes and their interaction with acetylcholinesterase

Autori
Primožič, Ines ; Baumann, Krešimir ; Tomić-Pisarović, Srđanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th Medical Chemical Defence Conference 2011 : Current Status of Terapeutic Approaches to Nerve Agent Poisoning / - München, Njemačka, 2011, 47-47

Skup
13th Medical Chemical Defence Conference 2011.

Mjesto i datum
München, Njemačka, 13-14.04.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Antidotes; mannoconjugates; oximes; AChE

Sažetak
In the attempt to improve the quality of antidotes against organophosphorus poisoning, heterocyclic oxime reactivators of inhibited AChE were linked to the sugar moiety. It was found that the attachement of a glucose to the oxime derivative increases the bioavailability of the antidote because they can mor easily cross blood-brain barrier and the antidote is retained longer in the blood circulation. Moreover, sugar analogs are in principle less toxic than the non-sugar analogs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Prirodoslovno-matematički fakultet, Zagreb