Structure of novel mannoconjugates with heterocyclic oximes and their interaction with acetylcholinesterase (CROSBI ID 596235)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Primožič, Ines ; Baumann, Krešimir ; Tomić- Pisarović, Srđanka
engleski
Structure of novel mannoconjugates with heterocyclic oximes and their interaction with acetylcholinesterase
In the attempt to improve the quality of antidotes against organophosphorus poisoning, heterocyclic oxime reactivators of inhibited AChE were linked to the sugar moiety. It was found that the attachement of a glucose to the oxime derivative increases the bioavailability of the antidote because they can mor easily cross blood-brain barrier and the antidote is retained longer in the blood circulation. Moreover, sugar analogs are in principle less toxic than the non-sugar analogs.
antidotes ; mannoconjugates ; oximes ; AChE
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Podaci o prilogu
47-47.
2011.
objavljeno
Podaci o matičnoj publikaciji
13th Medical Chemical Defence Conference 2011 : Current Status of Terapeutic Approaches to Nerve Agent Poisoning
München:
Podaci o skupu
13th Medical Chemical Defence Conference 2011
poster
13.04.2011-14.04.2011
München, Njemačka