engleski

BMI as a prognostic feature in patients with breast cancer treated with chemo/endocrine therapy

Introduction: High BMI has been associated with an increased risk for breast cancer among premenopausal and postmenopausal women. Several biological mechanisms play a significant role in the genesis and progression of breast cancer. Material and methods: This study aimed to investigate relationship between BMI and breast cancer diagnosis or progression in a Croatian population. BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 110 breast cancer women and compared with those of 110 healthy women prospectively. Results: BMI was significantly associated with a larger-tumour size (BMI ≥30 respect to normal weight, P=0.0047) and a higher probability of having positive axillary lymph node (P<0.0001). Conclusion: The analysis of pathological features of cancer indicates that normal weight women have a significantly higher probability of having a smaller breast cancer at time of diagnosis and negative axillary lymph nodes. BMI is an independent prognostic factor in patients with breast cancer treated with chemo/endocrine therapy in Croatian population.

BMI; breast cancer

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